Effect of PD-WEBB training on balance impairment and falls in people with Parkinson's disease / 中南大学学报(医学版)

OBJECTIVE@#To determine the effect of Parkinson's disease-weight bearing exercise for better balance (PD-WEBB) exercise on balance impairment and falls in people with Parkinson's disease (PD).@*METHODS@#A single-blind, randomized controlled clinical trial was conducted. The falls efficacy scale score, unified Parkinson disease rating scale (UPDRS) score and Mini-BESTest score were measured and compared between a PD-WEBB group and a control group.@*RESULTS@#The falls efficacy scale score, UPDRS-2 score, UPDRS-3 score and Mini-BESTest score were improved in the PD-WEBB group compared with the control group (P<0.05), with no significant change in UPDRS-1 score between the two groups.@*CONCLUSION@#PD-WEBB training can significantly improve the balance impairment and quality of life to prevent falls. PD-WEBB training is suitable for PD patients in China, and is a reasonable, effective and sustainable training of family and community assessment model.

Acute Myelitis in a Patient with Vogt-Koyanagi-Harada Disease: Case Report and Review of the Literature

BACKGROUND: Vogt-Koyanagi-Harada (VKH) disease is characterized by bilateral granulomatous uveitis with neurologic, auditory, and dermatologic manifestations. However, acute myelitis complicating VKH disease has rarely been reported. CASE REPORT: A 50-year-old Chinese Han woman presented with difficulty walking, numbness on the left side of the body, and difficulty with urination. The patient was diagnosed with incomplete VKH disease and received corticosteroid treatment prior to the neurological presentation. Acute myelitis was diagnosed based on both clinical and spinal-cord MRI findings. CONCLUSIONS: Clinicians should consider acute myelitis as a rare possible neurological manifestation in VKH disease patients, and early systemic administration of corticosteroids will suppress the acute inflammatory process and prevent recurrences. This report raises the possibility that VKH disease and acute myelitis share common pathogenic pathways.

Expressions and its relationship of vascular interleukin-6 and signal transducer and activator of transcription 3 in patients with giant cell arteritis / 临床神经病学杂志

Objective To investigate the expressions and its relationship of vascular interleukin-6(IL-6) and signal transducer and activator of transcription 3(STAT3) protein in giant cell arteritis patients.Methods The expressions of IL-6 and STAT3 protein were detected by immunohistochemistry in the temporal artery biopsy specimens of 20 patients with giant cell arteritis and 6 patients with other nerve system diseases(control group).Six indexs related to inflammation in giant cell arteritis patients were recorded.Giant cell arteritis patients were divided into the group that ≥3 positive indexs(7 cases) and the group that ≤2 positive indexs(13 cases).The relationship between expressions of IL-6 and STAT3 protein was analysed.Results Compared with control group[(2.00?0.63)score,(30.73?10.84)cell/H],the expressions of IL-6 and STAT3 protein in temporal artery were significantly increased in giant cell arteritis group[(2.85?0.75)score,(40.71?9.90)cell/H](all P