Sezary Syndrome In A Young Retropositive Male: A Rare Case Report

"Sezary syndrome, a rare disease, is the leukemic counterpart of mycosis fungoides accounting for less than 5% of cutaneous lymphomas. Very few case reports have been published of Sezary syndrome/mycosis fungoides presenting in young male and with coexisting HIV. We present a case of a 23-year-old retropositive male presenting with Sezary syndrome which is very rare. The present case highlights the fact that Sezary syndrome can rarely present in young and retropositive patients. It should be kept in differential diagnosis if a patient presents with erythroderma, generalized lymphadenopathy and characteristic peripheral smear findings. A multimodal approach involving flow cytometry, skin biopsy and fine needle aspiration cytology (FNAC) is required for arriving at a definite diagnosis."

Coexistant Extramedullary Hematopoiesisin Lymph Node And Non-Hodgkin Lymphoma With Leukemic Spill: A Rare Case Report

Extramedullary hematopoiesis (EMH) commonly occurs in the liver and spleen. Non-hepatosplenic EMH in a lymphnode is rare and with co-existing non-Hodgkin lymphoma is even rarer. Careful screening of cytological slides is a must in order not to miss such rare cases of non-hepatosplenic EMH in lymphnodes. We hereby report a rare case of a 75-year-old male with coexisting lymphnode EMH and NHL, that too with the leukemic spill, which has never been reported before.

A Clinicopathologic Study Of Chronic Subdural Haemorrhage With Special Emphasis On Cox–2 And Vegf Expression

Introduction: Chronic subdural haemorrhage is known for high recurrence rates. Recently, VEGF and COX2 have been implicated as causal agents for recurrences, which can be targeted to prevent repeated surgeries and reduce morbidity. Material and Methods: Retrospective study including all cases (n=40) of chronic subdural haemorrhage from 2013 to 2017. The membranes were classified into four histologic subtypes. COX 2 and VEGF antibodies were applied on all cases. Ap value of <0.05 was considered statistically significant. Results: Four subtypes were type 1: non inflammatory (22.5%), type 2: inflammatory (20%), type 3: haemorrhagic inflammatory (27.5%) and type 4: scar inflammatory (30%). Glasgow coma score less than 13 (30%), maximum mean thickness of subdural haemorrhage (6.88), highest VEGF positivity rate (100%) and highest COX 2 positivity rate (91.67%) were found in type 4 membrane [p value 0.003 and 0.0001]. Conclusion:We found that type 4 membranes had worst Glasgow coma score, maximum thickness on CT, highest positivity for VEGF and COX2. Therefore, these are likely to have maximum recurrences and hence can be targeted for anti COX 2 and VEGF therapy.