Efficacy Of Virechana Karma In The Management Of Acne Vulgaris

A healthy and clear facial impression plays the important part for the development of the personality. Since ages, Acne vulgaris has always been one of the most burning problem of the adolescents. It affects the most prominent part of our body, the face. Among the multifactorial etiology of acne hormonal imbalance and infections are most important. Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedones, open and closed) lesions. Propionibacterium acnes is responsible for the development of acne vulgaris. Acne Vulgaris can be correlated with Mukhadushika or Yuvanpidika on the basis of similarity in the etiopathogenesis, symptoms, treatment and complication. In Ayurveda it is the Shalmali thorn like eruptions on the face of adolescent due to vitiation of Kapha, Vata and Shonita. Allopathic treatment includes treatment for all forms of acne as topical retinoids and benzoyl peroxide, oral antibiotics, steroids etc. But these causes serious adverse effects. So it is necessary to find out effective and safe treatment for Acne Vulgaris. Ayurveda is for it which plays important role through its principles i.e. Shodhana, Shamana and Nidanparivarjana. As described by various Acharya the Shodhanachikitsa includes Vamana, Virechana and Shiravedha. Among Shodhana, Virechana process is the safe and effective treatment, providing long lasting result for better life of patient.

Indomethacin Exacerbates Oleic Acid-Induced Acute Respiratory Distress Syndrome in Adult Rats.

Acute respiratory distress syndrome (ARDS) is an acute fulminant condition associated with acute lung injury and inflammation leading to hypoxemia, pulmonary edema and respiratory failure. Even though prostaglandins are inflammatory mediators, the role of prostaglandins in ARDS is still not clear. Therefore, we examined the involvement of prostaglandin in experimentally induced ARDS by using prostaglandin synthesis inhibitor, indomethacin. Experiments were conducted on anesthetized adult rats (total n=15). Cannulation of trachea, jugular vein and carotid artery was done in these rats. Recording of respiratory excursions (for respiratory frequency; RF), ECG (for heart rate; HR) and blood pressure, before and after lethal dose of oleic acid (75 µL i.v.) was done for 120 min or till death of the animals. Arterial blood sample was collected 15 min after oleic acid injection to determine PaO2/FiO2 ratio. Lungs were excised at the end of experiment for estimation of pulmonary water content. Administration of oleic acid produced progressive increase in the RF up to 45 min followed by decrease. Subsequently, the respiration stopped and all the animals died by 75 min (mean survival time = 64±8.2 min). HR and mean arterial pressure (MAP) exhibited an immediate decrease followed by an increase up to 45 min. Thereafter, the HR and MAP progressively decreased. PaO2/FiO2 ratio in this group was 182±2.6 mm Hg and pulmonary water content was significantly greater than saline control group. However in indomethacin pretreated rats, injection of oleic acid produced instantaneous decrease in RF and all the animals died within 10 min (mean survival time = 6.6±1.07 min). HR and MAP followed the same pattern as seen with RF. Pulmonary water content in indomethacin pretreated animals was also significantly greater than control group. These observations indicate that indomethacin exacerbates the OA-induced ARDS. Thus, prostaglandins play an important role in the pathophysiology of OA-induced ARDS.

Pregnancy Following Surgery Of Multiple Pelvic Hydatid Cysts.

Abstracts: Background: Hydatid cyst in pelvic region is very rare. A patient was admitted in Gynaec ward with complaints of , lump and pain in lower abdomen and, constipation since, five months. General examination was normal. Abdominal and gynaecological examination lead to diagnoses as ovarian cyst ? Multiple uterine subserous fibroids? Ultra sonography diagnosis was Hydatid cysts abdomen / Mucininious cystadenoma ovaries . CT Scan abdomen and pelvis confirmed USG findings of Hydatid cysts. On Laprotomy multiple hydatid removed from pelvic region , omentum , ileocaecal junction and liver . Patient put on chemotherapy and follow up was satisfactory.

Sphygmomanometric Blood Pressure Drop on Consecutive Measurements : The Search for a Cause.

This study was inspired by our oft-noted observation that the first sphygmomanometric reading of blood pressure (BP) is invariably higher than the subsequent ones recorded immediately thereafter. The objectives of this study were to establish the statistical validity of this observation and further, to probe the possible causes of the same. The sphygmomanometric BP was recorded in 30 non-obese young adults using two different protocols. In protocol-1, BP in the left arm was repeated thrice in quick succession, both in standing and supine postures. In protocol-2, BP was recorded in the supine position six times in quick succession, thrice in the left arm and immediately thereafter, thrice in the right arm. Data was compiled and analysed using appropriate statistical tests. In protocol-1, a statistically-significant drop in the blood pressure was consistently noted between quickly consecutive measurements in both standing and supine postures. Importantly, this pressure drop was not significantly affected by posture. In protocol-2, significant pressure drop was recordable from both arms. These findings rule out baroreflex as a cause of the pressure-drop on consecutive measurements and suggest a likely role of tissue compaction in the same.

Characterization of oleic acid-induced acute respiratory distress syndrome model in rat.

Animal studies using oleic acid (OA) model to produce acute respiratory distress syndrome (ARDS) have been inconsistent. Therefore, the present study was undertaken to establish an acute model of ARDS in rats using OA and to characterize its effect on cardio-respiratory parameters and lethality. The trachea, jugular vein and femoral artery of anesthetized adult rats were cannulated. A dose of OA (30-90 µL; iv) was injected in each animal and changes in respiratory frequency (RF), heart rate (HR) and mean arterial pressure (MAP) were recorded. Minute ventilation and PaO2/FiO2 (P/F) ratio were also determined. At the end, lungs were excised for determination of pulmonary water content and histological examination. At all doses of OA, there was immediate decrease followed by increase in RF, however at 75 and 90 µL of OA, RF decreased abruptly and the animals died by 63 ± 8.2 min and 19 ± 6.3 min; respectively. In all the groups, HR and MAP changes followed the respiratory changes. The minute ventilation increased in a dose-dependent manner while the values of P/F ratio decreased correspondingly. Pulmonary edema was induced at all doses. Histological examination of the lung showed alveolar damage, microvascular congestion, microvascular injury, infiltration of inflammatory cells, pulmonary edema and necrosis in a dose-dependent manner. With these results, OA can be used to induce different grades of ARDS in rats and OA doses of 50, 60 and 75 µL resemble mild, moderate and severe forms of ARDS respectively. Hence, OA model serves as a useful tool to study the pathophysiology of ARDS.

ICDS — is it the entitlement of every Indian child.

Objectives: To assess the extent of utilization of services by underthree & their mothers at AWC’s & to study the gender differences in availing the services . Methods : A cross- sectional study regarding the utilization of services by children (0-3 years) & their mothers among 11 Anganwadis in 8 villages registered under RHTC,HIHT Dehradun. The data was tabulated on Microsoft Excel sheet and analyzed using the software SPSS 17.0 for Windows. Results : Study findings showed that majority of underthree children i.e. 89.2% were enrolled in the AWCs whereas only 29.20 % went to AWCs to avail the combined benefits of vaccination, supplementary nutrition, healthcheckups followed by Immunization services(23.2%).63.55% children in the age group 0-3 years were attending the AWC to receive SN whereas only 22% of children were availing it regularly. Conclusion: The problems encountered at AWCs were under utilization of services due to lack of awareness of parents & insufficient motivation of AWW. There is a need to improve awareness about the services especially in the underthree age group so that eligible beneficiaries can avail them.

Cereals Nutraceuticals, Health Ennoblement and Diseases Obviation: A Comprehensive Review.

Nutraceuticals have time-honored considerable interest because of their reputed safety, nutritional and therapeutic potential effects. Pharmaceutical and nutritional industries are conscious of the monetary success taking advantage of the more health-seeking consumers. Natural products such as cereals are likely to form the basis of nutraceutical as its revolution represents an enormous opportunity for growth and expansion. Wheat, rice, millets, barley, oat, buckwheat ,corn ,sorghum, flaxseed psyllium, brown rice, and products are notify the most common cereal based functional foods and nutraceuticals. The nutrients in the cereals have identified prospective for reducing the risk of coronary heart disease, diabetes, tumor incidence, cancer risk, blood pressure, reduces the rate of cholesterol and fat absorption, delaying gastrointestinal emptying and providing gastrointestinal health. Thus, the regular insertion of cereals and their processed products can make a payment to health endorsement and disease avoidance.