Chromatographic and spectrophotometric analysis of panchronium bromide.

The present investigation is centered on drug pancuronium bromide, which is a muscle relaxant basically used in clinical practice for an aesthetic purposes. Few rape cases have been reported where in this drug was used to incapacitate the rape victim. All this highlights the abuse potential of Pancuronium bromide in crime related to rape. Testing/analyzing Pancuronium bromide by making use of body material and other traces present in the surrounding of victim/crime scene will be of great importance for medico legal purpose and forensic view point. In the present study an attempt has been made to analysis Pancuronium bromide by chromatographic (TLC and HPLC) and UV-SPECTROPHOTOMETRY. In spite of the limitation the conclusions reached in the present study are of considerable forensic significance.

Comparative study of known nonsteroidal antiinflammatory drugs with glycosidal fraction isolated from Maesa chisia D. don var angustifolia Hook F and Th.

Antiinflammatory, analgesic and antipyretic activities of glycosidal fraction isolated from M. chisia were compared in battery of animal tests with known nonsteroidal antiinflammatory drugs (NSAIDs). The pharmacological activities compared favourably with NSAIDs whereas remarkable lack of toxicity was an added advantage.