1.
Effects of diltiazem on calcium ion translocation: a study on isolated frog rectus abdominis muscle.
Indian J Physiol Pharmacol
;
1995 Jan; 39(1): 83-5
Artigo
em Inglês
| IMSEAR
| ID: sea-107732
RESUMO
Diltiazem, a calcium channel blocker was studied to observe its effects on the acetylcholine contractile responses of isolated frog rectus abdominis muscle. This response was modified in a dual manner i.e., initial potentiation, followed by inhibition. Diltiazem may not have anticholinesterase like mechanism, as it potentiated the responses to both acetylcholine and succinylcholine. Rectus muscle preparation, incubated in calcium free frog Ringer, showed dose dependent inhibition of acetylcholine contractile responses by diltiazem. The study suggests that diltiazem inhibits calcium ion influx across receptor operated calcium channels and may also inhibit calcium ion release from intracellular structures.
Assuntos
Acetilcolina/antagonistas & inibidores , Animais , Anuros , Cálcio/metabolismo , Canais de Cálcio/efeitos dos fármacos , Diltiazem/farmacologia , Relação Dose-Resposta a Droga , Sinergismo Farmacológico , Contração Muscular/efeitos dos fármacos , Reto do Abdome/efeitos dos fármacos , Succinilcolina/antagonistas & inibidores
2.
Indian J Physiol Pharmacol
;
1989 Jul-Sep; 33(3): 199-200
Artigo
em Inglês
| IMSEAR
| ID: sea-107318
3.
Indian J Physiol Pharmacol
;
1974 Oct-Dec; 18(4): 330-3
Artigo
em Inglês
| IMSEAR
| ID: sea-107824