Pharmacokinetics mechanism of ABC efflux proteins-mediated seven features of compatibility / 中国中药杂志

ABC efflux proteins are a kind of transporters mediating diversified endogenous and exogenous efflux protein substrates across the plasma membrane by depending on the chemical energy released by ATP hydrolysis. As a vitally important functional membrane, it is widely found in various tissues and organs. The drug changes the expressions and/or functions of the transport proteins, which will affect the disposal process of substrate drugs corresponding to transporters , and finally lead to the pharmacokinetic interactions. The efflux proteins take part in the absorption, distribution, metabolism and excretion of drugs, and mainly consist of P-glycoprotein(P-gp), multidrug resistance associated protein(MRP) and breast cancer resistance protein(BCRP). The induction effect or inhibition effect of drugs on efflux protein plays a greatly significant role in the drug interaction produced by the compatibility of traditional Chinese medicine, which may be one of the important mechanisms of the theory of seven features of compatibility. In this article, the effects of seven features of compatibility on the ABC efflux transporters were reviewed, in order to reveal the roles of efflux protein in the herb-pairs compatibility, and provide new ideas for the mechanism and rationality of herb compatibility.

Advances on Chinese materia medica-chemical drug interactions mediated by P-glycoprotein / 中草药

Chinese materia medica (CMM) in combination with chemical drug is an effective treatment for diseases. CMM sustain moderate effect, including multiple components, multiple targets, multiple pathways and integrated regulation characteristics; While the effect of chemical drug is rapid and shows definite target and single way, the combination of the two can be complementary advantages, synergistic effects and reduce toxicity. P-glycoprotein (P-gp) is a kind of energy dependent transmembrane transport protein; Its mediated efflux effect is one of important targets for drug delivery. The induction or inhibition of P-gp plays a significant factor in the interaction generated when CMM and chemical drug combined application. In this paper, interaction of CMM combined with chemical drug in P-gp level was briefly reviewed, in order to reveal the role of P-gp in joint use Chinese and Western medicine, and to provide reference for the rational use of drugs to integration of Chinese and Western medicine in clinic.

C21 steroids from the stems of Marsdenia tenacissima / 药学学报

To study the C21 steroids of the stems of Marsdenia tenacissima (Roxb.) Wight et Arn, various chromatography methods were used for the isolation of the constituents and their structures were identified by spectral analysis. Eight C21 steroids were isolated from the CHCl3 extract, which were identified as 11alpha-O-tigloyl-17beta-tenacigenin B (1), 17beta-tenacigenin B (2), tenacigenoside A (3), 11alpha-O-2-methylbutyryl-12beta-O-acetyl tenacigenin B (4), tenacissoside H (5), marsdenoside A (6), tenacissoside G (7), and tenacissoside I (8). Among them, compound 1 is a new compound.