RESUMO
In an attempt to understand the toxicity and the potential role of gamma-radiation as a therapeutic tool, the effects of different Gamma-radiation doses on haematological and dimensional properties of rats' blood were investigated in vivo. 60 healthy male Wistar-Kyoto rats were used, which were randomly divided into five groups, 4 Gamma-radiated rat groups [1St group was radiated with five Gamma-radiation dose, 2nd group 25Gy; 3rd group with 50Gy, 4th group with 100Gy, and 5th group was control]. Different haematological and dimensional parameters were measured using the standard haematological technique. A significant decrease in red blood cells [RBCs] count, haemoglobin [HGB], and haematocrit [HCT] was observed compared with the control. While a significant increase in mean corpuscular volume [MCV], mean corpuscular haemoglobin [MCH] and mean corpuscular haemoglobin concentration [MCHC], red distribution width [RDW] were observed compared with the control. This study suggested that low RBCs, HGB, and HCT might produce anemia and cessation of erythrocytes production in the bone marrow. Moreover, the RBCs size increase might be attributed to changes in the morphology and deformability of RBCs, which was confirmed by a slightly increase in RDW
RESUMO
Serum iron, zinc and copper concentrations in Rheumatoid Arthritic [RA] patients as compared to normal controls were measured. Serum calcium, magnesium, phosphorus concentrations, and alkaline phosphatase activity as well as 1, 25 [OH][2] Vitamin D in RA patients as compared to normal controls were measured. In addition, Hemoglobin derivatives, and the dielectric relaxation in the frequency range 100 KHz up to 10 MHz of Hb molecules of RA patients compared to normal controls were measured. It was found that a significant increase in Met-Hb, abnormal dynamic motion of Hb and changes in the overall shape of Hb. Also, The dielectric results indicated that the molecular shape of hemoglobin tends to deviate from the spherical form as the disease geos to the severity