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Chinese Journal of Integrated Traditional and Western Medicine ; (12): 445-448, 2006.
Artigo em Chinês | WPRIM | ID: wpr-230184

RESUMO

<p><b>OBJECTIVE</b>To observe the clinical effect of the combined use of amiodarone and Wenxin Granule (WXG) in auricular fibrillation (AF) conversion and its safety.</p><p><b>METHODS</b>Two hundred and twenty-four patients, in whom AF lasted for less than 1 year, were enrolled and randomly assigned into two groups, 112 in each group. Patients in the treated group were treated with WXG and amiodorane and the others in the control group were orally administered with amiodarone alone. The accumulative conversion rate of AF and adverse reaction were monitored during the 6-month observation period.</p><p><b>RESULTS</b>Six-month observation was completed in 109 cases in the treated group and 107 in the control group, while 3 cases and 5 cases in the two groups were dropped out respectively. The difference of accumulative AF conversion rates between the two groups become significant early after one month medication (P < 0.05), and was 65.1% and 47.7% respectively after 6-month of treatment (P < 0.05). Inter-group significant difference was also shown in the aspects of average conversion time, dosage of amiodarone required and the occurrence of adverse reaction (P < 0.05).</p><p><b>CONCLUSION</b>Combined use of WXG and amiodarone has a better effect in improving conversion rate of AF, shortening conversion time and decreasing the required dosage of amiodarone in treating AF as compared with the treatment with amiodarone alone, and by which the adverse reaction of long-term using amiodarone could be avoided.</p>


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Amiodarona , Usos Terapêuticos , Antiarrítmicos , Usos Terapêuticos , Fibrilação Atrial , Tratamento Farmacológico , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Fitoterapia , Segurança
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