Advance in mechanism and application of antibacterial peptide / 中国生化药物杂志

In the era of outbreaking of antibiotic resistance, the discovery of new antibacterial drugs is emergent.Antimicrobial peptides are important components of the natural defenses of most living organisms against invading pathogens.The unique antibacterial mechanism, direct bactericidal effect, relatively slow of resistance acquirement, and can used alone or combined with antibiotics, make antimicrobial peptides be attractive potential antibacterial drugs.In this paper, we review the physicochemical property of antibacterial peptides, action mechanism and design of antimicrobial peptides, and give a brief introduction of several promising antimicrobial peptides.

Comparative Study of High Frequency Ultrasonography and CDFI with Pathology in Diagnosis of Breast Tumor / 实用放射学杂志

Objective To evaluate the diagnostic role of high frequency ultrasonography(HFU) and CDFI for breast tumor,especially to evaluate the correlation of pathology in hyperplasia of breast.Methods HFU and CDFI findings were compared with pathological study in 196 cases with confirmed breast tumor.The tumor of breast were divided into three groups.They were 81 cases of fibrocystic disease ofbreast,70 cases of breast cancer and 45 cases of fibroadenoma disease of breast.Results The benign and nicious tumor of breast haddifferent and typical represent of HFU,because dates of HUF had correlation with those of pathology,such as tumor boundary,internalecho,mononode and multinode,calcification,attenuation and CDFI.Some patients had crossed represent of HUF and CDFI.Thesensitivity,specificity and accuracy rate were calculated apart from.The sensitivity of fibroscystic disease of breast was 89%,the specificity was 96.5%,the accuracy was 93%,the negative predictive value was 93%,the postive predictive valus was 95%;the sensitivity of cancer of breast was 89%,the specificity was 94%,the accuracy was 92%,the negative predictive value was 96%,the post predictive valus was 89%;the sensitivity of fibroadenoma of breast was 89%,the specifity was 93%,the accuracy was 92%,the negative predictive value was 96%,the postive predictive value was 80%.Conclusion HUF in combination with CDFI are useful in diagnosis of both male and female breast tumor.This study may be helpful in raising the ultrasonic diagnosis rate in breast tumor.