Clinical observation of Qingrehuatan method in the treatment of insomnia elderly patients with benzodiaz-epines dependence / 中国基层医药

Objective To investigate the clinical curative effect of Qingrehuatan method in the treatment of insomnia elderly patients with benzodiazepines dependence.Methods From April 2016 to April 2017,49 insomnia elderly patients with benzodiazepines dependence in the Second People's Hospital of Zhoushan were divided into the observation group(20 cases)and control group (29 cases)according to the different treatment methods.In the gradual reduction at the same time,the control group was treated with trazodone,the observation group was treated with Qingrehuatan method.Before treatment and after treatment for 1course,the revised Pittsburgh sleep quality scale (PSQI),index of insomnia symptom score,TCM symptom score,Zung Anxiety Rating Scale score,Wechsler Adult Intelligence Scale(WAIS－RC)and Wechsler Memory Scale(WMS－RC)score were observed in the two groups. Results After treatment,the rate of withdrawal and discontinuation of the observation group was significantly higher than that of the control group (90.0% vs.68.9%),the difference was statistically significant (χ2＝6.918,P＜0.05).After treatment,the PSQI scores and symptom scores of the two groups were significantly decreased,and the PSQI scores and TCM symptom scores of the observation group improved significantly better than those of the control group[(8.8 ±1.1)points vs.(10.6 ±1.3)points,(2.9 ±0.8)points vs.(4.6 ±1.2)points],the differences were statistically significant(t＝5.063,5.535,all P＜0.05).After treatment,the Zung Anxiety Scale scores of the two groups were significantly lower,and the improvement of the observation group was significantly better than that of the control group[(42.90 ±5.65)points vs.(48.21±5.27)points],the difference was statistically significant(t ＝ 3.366,P＜0.05 ).After treatment,the long －term memory,short －term memory and memory quotient of the two groups were significantly increased,and short－term memory and memory quotient of the observation group improved significantly better than those of the control group[(23.30 ±5.31)points vs.(20.55 ±6.58)points,(76.67 ± 12.70)points vs.(67.36 ±19.13)points],the differences were statistically significant (t＝2.274,2.047,all P＜0.05 ).Conclusion Qingrehuatan method in the treatment of insomnia elderly patients with benzodiazepines depend-ence can improve the possible reduction in the process of stopping drug withdrawal symptoms and memory function, and can improve the symptoms of patients at the same time,and it is worthy of clinical application.

The relationship between serum thyroid stimulating hormone and thyroid cancer / 中国生化药物杂志

Objective To investigate the correlation between the incidence of thyroid carcinoma and TSH, and to provide evidence for clinical application.MethodsSelect 450 cases of patients with thyroid from August 2014 to August 2016 in our hospital as the object of study in this group, the analysis of gender and age of patients, lymph nodes, tumor, laboratory examination results, to explore the relationship between TSH levels and thyroid cancer.ResultsThyroid patients with TSH was significantly higher than that in benign tumor group (P<0.05);the level of TSH and patients with lesion diameter, tumor stage, lymph node metastasis and capsule invasion was significantly correlated (P<0.05), but the level of TSH and age, gender, tumor number, vascular invasion and no significant correlation;TSH the level of thyroid cancer patients were significantly increased (P<0.05).ConclusionThe level of TSH in serum is closely related to the occurrence and development of thyroid cancer, and is closely related to lymph node metastasis and tumor stage, and the higher TSH level can increase the risk of thyroid cancer.

Analysis on endocrine and metabolic features of different phenotypes of polycystic ovary syndrome patients

To discuss the manifestations of endocrine and metabolism for polycystic ovary syndrome patients with different phenotype. This study selected 226 cases of Rotterdam Standard diagnosed polycystic ovary syndrome patients in People's Hospital of Zhengzhou from October 2013 to February 2015. The control group was the 100 cases of non hyperandrogen menstrual women as the control group. Polycystic ovary syndrome included 4 phenotype: /or anovulatio [O] combined with hyperandrogenism [H] and polycystic ovary morphology [P], phenotype of O and P, phenotype of H and P, and phenotype of O and P. All patients were detected for the clinical endocrine and metabolism related parameters. The phenotype of O and P occupied 55.8%, it had significant difference on the comparison between control group and the luteinizing hormone [LH] and luteinizing hormone/follicle stimulating hormone [LH/FSH] of phenotype of O, H and P, phenotype of O and H and phenotype of O and P; the testosterone [T] of phenotype of O,H and P and phenotype of O and H was apparently higher than phenotype of O and P and control group; The total cholesterol [TC] and triglyceride [TG] in phenotype of O, H and P was greatly higher than phenotype of O and P and control group. The phenotype of O and P was the most common phenotype in PCOS patients. It was same for the clinical endocrine and metabolism of two classic characteristics in PCOS. Compared to other PCOS phenotype, the metabolism in phenotype of O and P was lower. The phenotype classification of PCOS patients could better guide clinical individualized treatment in patients with PCOS

Cost-Effectiveness Analysis of 4 Therapeutic Schemes for Vulva Condyloma / 中国药房

OBJECTIVE:To evaluate the cost-effectiveness of 4 therapeutic schemes for vulva condyloma. METHODS:228 patients with vulva condyloma were randomly divided into four groups based on their visiting time:Group A (drug therapy alone),Group B (Leep knife plus drug therapy),Group C (CO2-Laser plus drug therapy),Group D (Microwave plus drug therapy). The cost-effectiveness analysis was conducted on the 4 schemes applying the principle in pharmacoeconomics. RESULTS:The costs of four groups were 264.25,557.82,1 065.31 and 1 485.76 Yuan respectively. The effective rates of four groups were 42.1%,83.3%,85.7% and 89.7% respectively. Compared with scheme A,the incremental cost-effectiveness ratio in schemes B,C,and D were 712.55,1 837.29,and 2 566.20 respectively. CONCLUSION:Pharmacoeconomically,Group B (Leep knife plus drug therapy) is the optimal therapy for vulva condyloma.

Quality Standard of Zhikuoning Mixture / 中国药房

OBJECTIVE:To establish the quality standard of Zhikuoning mixture.METHODS:Scutellaria baicalensis,Morus alba,Citrus aurantinm,Salvia miltiorrhiza in the preparation were identified by TLC,and the content of baicalin in Zhikuoning mixture was determined by HPLC.RESULTS:The TLC spots were clear and well-isolated yet without interference from negative control.The linear range of Baicalin was 15.81～252.96 ?g?mL-1(r=0.999 9)and its average recovery was 101.8%(RSD=1.80%,n=9).CONCLUSION:The established quality standard can be used for the quality control of Zhikuoning mixture.