RESUMO
Background: Non-Alcoholic fatty liver disease (NAFLD) has become a worldwide health concern with increase in the global incidence of obesity and it is now considered the hepatic component of the metabolic syndrome. Aims and Objective: The study’s aim was to compare the indices of the Liver Function tests in compensated chronic liver disease patients with and without NAFLD. Materials and Methods: A total of 100 consecutive patients with compensated chronic liver disease were recruited into the study. A structured questionnaire was administered to obtain relevant socio-demographic data. NAFLD was diagnosed based on clinical, biochemical, ultrasonographic and in a few histological features. The Adult Treatment Panel III criteria were used to identify patients with the metabolic syndrome. Results: In our study, 100 participants were recruited into study. 40 out of 60 patients (67%) showed grade-1 fatty liver findings and 20 out of 60 patients (33%) showed grade-2 fatty liver. Approximately 19% had fatty liver finding. The mean (SD) age of persons with NAFLD was 45.12 (±8.07) years compared to 47.49(±11.79) years for persons without NAFLD. The difference was not statistically significant (p=0.2). Body mass index (BMI), central obesity (waist circumference), fasting blood sugar, blood pressure, total cholesterol and triglycerides were significantly higher in the NAFLD group (p= <0.05) respectively. Conclusion: Indices of the deranged Liver functions were more prevalent in persons with NAFLD. It is recommended that patients with NAFLD be screened for metabolic syndrome and appropriate therapy instituted to decrease the risk of both hepatic and cardiovascular complications.
RESUMO
Background: Tobacco & Alcohol consumption has many worsthealth outcomes. Tobacco is consumed in many forms andone such form is cigarette smoking. Tobacco use leads tosudden coronary death, chronic obstructive pulmonarydisease, cancer, peripheral vascular disease, hypertension andthe list is endless. Alcohol is consumed in hard drink form.Alcohol is use leads to liver disease, brain damage, heartdisease, pancreatitis, cancer risk and the list is endless.Aim: To evaluate ECG intervals in apparently healthy youngmale smokers compared to non-smokers & Drinkers comparedto non-drinkers using a 12-lead ECG record.Objective: To evaluate and compare variations in ECG waves,segments and intervals in apparently 150 healthy young malesmokers , non-smokers and 150 drinkers, non-drinkers.Materials and Methods: Descriptive comparative study overtotal duration of 24 months. For convenience 300 young,apparently healthy smokers non-smokers, Drinkers and nondrinkers in the age group of 18 - 35 yrs. were taken.Settings and Design: Department of General Medicine OPDof Vedantaa Institute of Medical Sciences, Palghar (TertiaryCare Hospital).Results: PR interval was significantly shortened amongsmokers & drinkers. No statistically significant difference inQRS interval between the two groups (Smokers & nonSmokers) but statistically significant difference in QRS intervalbetween the two groups (Drinkers & Non Drinkers). QTcinterval was slightly higher among smokers than non-smokersalso drinkers than non-drinkers. TP interval was slightly higheramong non-smokers than smokers also non-drinkers thandrinkers. There is statistically significant decrease seen insmokers & drinkers.Conclusion: Smoking & Drinking induces significantalterations in cardiac electrophysiology like shortening of PRand TP interval, prolongation of the QTc interval in apparentlyadult male individuals which may predispose to cardiovascularmorbidity and mortality in the long run.