RESUMO
Background: The clinical consequences of hypothyroidism and hypothyroxinemia during pregnancy such as preterm birth are not still clear
Objective: The aim of this meta-analysis was to estimate the relation of clinical and subclinical hypothyroidism and hypothyroxinemia during pregnancy and preterm birth
Materials and Methods: In this meta-analysis, Preferred Reporting Items for Systematic review and Meta-Analysis were utilized. Searching the 83T cohort studies 83T were done by two researchers independently without any restrictions on Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO and Google Scholar databases up to 2017. The heterogeneity of the studies was checked by the Cochran's Q test and IP2P index. Both random and fixed-effects models were used for combining the relative risk and 95% confidence intervals. Data were analyzed using Comprehensive Meta-Analysis software version 2
Results: Twenty-three studies were included in the meta-analysis. The relative risks of the clinical hypothyroidism, subclinical hypothyroidism and hypothyroxinemia during pregnancy on preterm birth was estimated 1.30 [95% CI: 1.05-1.61, p=0.013, involving 20079 cases and 2452817 controls], 1.36 [95% CI: 1.09-1.68, p=0.005, involving 3580 cases and 64885 controls] and 1.31 [95% CI: 1.04-1.66, p=0.020, involving 1078 cases and 44377 controls], respectively
Conclusion: The incidence of preterm birth was higher among mothers with clinical and subclinical hypothyroidism or hypothyroxinemia during pregnancy compared to euthyroid mothers, and these relations were significant. Therefore, 83T gynecologists and endocrinologists 83T should manage these patients to control the incidence of 83T adverse pregnancy outcomes 83T such as preterm birth
RESUMO
Background: infant low birth weight is one of the major problems in different societies. Different reports have provided different results regarding the relationship between maternal anemia and infant low birth weight in different months of pregnancy
Objective: the aim of this study was to determine the relationship between maternal anemia during pregnancy and infant low birth weight
Materials and Methods: this systematic review was conducted using related keywords in national [Sid, Iran.doc, Iran medex and Magiran] and international [PubMed, Science Direct, Cochrane, Medline, Web of Science, Scopus, Springer, Embase, Google scholar] databases. Relative risks and confidence intervals were extracted from each study. The results were combined using random-effects model for meta-analysis. The I[2] index was also used to measure heterogeneity between the studies
Results: overall, 17 studies with a total sample size of 245407 entered the final meta-analysis and demonstrated that the relative risk for maternal anemia in the first, second and third trimester of pregnancy were 1.26 [95% CI: 1.03-1.55], 0.97 [95% CI: 0.57-1.65], and 1.21 [95% CI: 0.84-1.76], respectively. The relationship between maternal anemia and infant low birth weight in the first trimester of pregnancy was significant
Conclusion: maternal anemia, especially during the first trimester of pregnancy, can be considered as a risk factor for pregnancy outcomes. Therefore, one needs to take the necessary steps to cure this disease in order to reduce the incidence of infant low birth weight