Spontaneous internal carotid artery dissection / 国际脑血管病杂志

Spontaneous internal carotid artery dissection is a group of (c)linical uncommondiseases,but it is a potentially catastrophic non-traumatic acute critical illness.The improvement of knowledge and understanding of the disease by clinicians will help to take preventive measures and improve the levels of diagnosis and treatment.This article reviews the advances in clinical features,diagnosis and treatment of spontaneous internal carotid artery dissection.

Clinical diagnosis and treatment for intracranial vertebrobasilar artery dissection / 国际脑血管病杂志

Intracranial vertebrobasilar artery dissection (VBAD) is not uncommon in clinical practice. Its onset form primarily manifested as subarachnoid hemorrhage or posterior circulation ischemia. It is very easy to be misdiagnosed because lack of the specific symptoms and signs. This article reviews the clinical manifestation, imaging characteristics and treatment of intracranial VBAD in order to improve the early diagnostic rate of the disease, reaching the purposes of early treatment, reducing complications and improving the prognosis.

Acute ischemic stroke patients without angiographically revealed arterial occlusion / 介入放射学杂志

Approximately 20%-30% of the patients with acute ischemic stroke do not have an angiographically demonstrable arterial occlusion. This article reviews the possible explanations for the absence of angiographically documented occlusion, the risk and the occurrence rate of cerebral infarction, the prognosis, and the effectiveness as well as the safety of thrombolytic therapy.

An outbreak of Guillain-Barré syndrome from Shuangyang district of Changchun, China / 中华神经科杂志

Objective To clearify the features of an outbreak of Guillain-Barré syndrome (GBS) from Shuangyang district of Changchun city, Jilin province, China.Methods Serum samples obtained were tested serologically for antibodies to chlamydia, coxsackie virus, cytomegalovirus, and hepatitis B virus.Stool samples obtained were cultivated to search Campylobacterjejuni.Electrudiagnostic studies were done 1 day after onset to 10 days.Results Twenty-two patients (12 males and 10 females, aged 15-71 years) were from Shuangyang district, a suburb of Changchun, during a 2-week period in June to July 2007.An illness in the preceding 4 weeks was reported in 17 patients, 16 gave a history of diarrhoea, 1 patient had symptoms consistent with an "upper respiratory infection" and 1 patient had both.Limb weakness were the earliest symptoms.Respiratory assistance was needed by 3 patients.Tendon reflexes were lost as weakness developed.Eleven patients had raised concentrations of protein in the cerebrospinal fluid ((0.74±0.32) g/L), and the averaged cell count was 3×106/L There were 3 kinds of antibodies of hepatitis B virus positive above 17 GBS patients.Electrodiagnostic studies showed severe reductions in motor evoked amplitudes from distal stimulation in 12 patients.Sensory action potentials were normal.Conclusions The distinctive epidemiologicai, clinical and electromyography characteristics of these patients suggest that the disorder, different from acute inflammatory demyelinating polyneuropathy, is concordant with acute motor axonal neurupathy.The features of Shuangyang GBS was similar to those previously reported in several aspects.

Ballon angioplasty and stenting for acute ischemic stroke / 国际脑血管病杂志

Thrombolytic agents for the treatment of acute ischemic stroke have some limitations. Balloon angioplasty and stenting have become the research hotspot in the treatment of acute ischemic stroke. 1his article reviews the effectiveness and safety of balloon angioplasty and stenting in the treatment of acute ischemic stroke.

Therapeutic Window Concentration of Tacrolimus: Survey of 56 Cases of Renal Transplant Recipients / 中国药房

OBJECTIVE: To explore the therapeutic window concentration of tacrolimus(FK506) suitable for Chinese renal transplant recipients. METHODS: The whole blood valley concentration level in 56 renal transplant recipients 12h after oral administration with FK506 was determined by MEIA (Microparticle Enzyme Immunization). The rejections and the renal toxic reaction were observed as well. RESULTS: The recommended therapeutic window concentration of FK506 for Chinese renal transplant recipients were the following: 9～14?g/L during the first month; 8～12?g/L during the second to the third month; 6～10?g/L during the fourth to the sixth month; 4～6?g/L during the seventh to the twelfth month. CONCLUSION: FK506 has a satisfactory immune suppression effect while reducing incidences of rejections and renal toxic reactions if used within the above therapeutic window concentration.

Cost - effectiveness Analysis of Levof loxacin in Treating Lower Respiratory Tract Infections: Survey of 2 Dose Regimen / 中国药房

0.05), respectively; the costs were 640.50yuan and 1 151.21yuan, respectively; the cost-effectiveness ratios were 7.01 and 12.28, respectively; the incremental cost-effectiveness ratio of Group B versus Group A was 220.1. CONCLUSION: The sequential therapy of levofloxacin is preferable in the treatment of lower respiratory infection.

Discussion on Therapeutic Window Concentration of Digoxin / 中国药房

0.05),the toxi?cation rate of the low dose group was lower than that of the routine group(P0.05),the effective concentration of the low dose digoxin group was significantly lower than the routine group(P

The effect of yizhi oral liquid on the learnign and memory of chronic cerebral inchemic dementia rat / 中国组织工程研究

Objective To explore treatment effect of (chinese drog)Yizhi oral liquid on chronic cerebral ischemic dementia rat.Methods Dementia rat model was made by ligating bilateral comon carotid artery and detect the ability to learning and memory in the therapeutic group,ischemic group and control group. Results The scores of water maze experiment in therapeutic were more higher than in ischemic group. Conclusion Yizhi oral liquid can improve the ability of learning and memory of rats.

Monitoring of Peak Blood Concentration in Renal Transplant Recipients 2h after Oral Administration of Cyclosporine A and Study on Therapeutic Window Concentration / 中国药房

OBJECTIVE:To study the therapeutic window of peak blood concentration at different time in domestic renal transplant recipients2h after administration with cyclosporine A(CsA).METHODS:The valley bottom levels(C 0 )and the peak levels(C 2 )were determined simultaneously by fluorescence polarization immunoassay(FPIA)in92patients2h after oral administration with CsA,the rejection and the hepatic and renal drug toxicities were observed.RESULTS:The recommended therapeutic window concentration of CsA(C 2 )in Chinese renal transplant recipients was1000～1300?g/L within the first month,950～1250?g/L within the second to third month,900～1100?g/L within the fourth to sixth month,750～1000?g/L within the seventh to twelfth month,600～800?g/L from the twelfth month after renal transplantation.CONCLUSION:Within the above therapeutic window concentration range,CsA is of ideal immuno-suppressive action meanwhile it can less rejection and minimize the hepatic and renal drug toxicities.