Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion

Background@#and Purpose Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify the factors associated with collateral circulation, especially blood lipids. @*Methods@#The study involved patients who had undergone digital subtraction angiography and were confirmed as having severe unilateral stenosis or occlusion of the internal carotid artery (ICA). We classified the collateral circulation status of each patient as good (Grade 3 or 4) or poor (Grade 0, 1, or 2) according to the grading system of the American Society of Interventional and Therapeutic Neuroradiology/American Society of Interventional Radiology. We collected data on patients’ characteristics and identified the factors that affect collateral circulation. @*Results@#This study included 212 patients. The multivariate logistic regression analysis showed that the high-density lipoprotein cholesterol (HDL-C) concentration and a complete anterior half of the circle of Willis were independent protective factors for good collateral circulation, whereas elevated lipoprotein(a) [Lp(a)] and serum creatinine concentrations were independent risk factors for good collateral circulation. The area under the receiver operating characteristics curve (AUC) was 0.68 (95% confidence interval [CI], 0.61–0.76) for HDL-C and 0.69 (95% CI, 0.62–0.76) for Lp(a). A binary logistic regression model analysis of the joint factor of HDL-C and Lp(a) yielded an AUC of 0.77 (95% CI, 0.71–0.84). @*Conclusions@#In patients with severe unilateral ICA stenosis or occlusion, the combination of HDL-C and Lp(a) is a useful predictor of collateral circulation.

Application and development of liposome injection / 中国药科大学学报

@#Liposome injection is one of the most successful special injections that use nanotechnology to enhance drug efficacy and reduce accompanied toxicity. New liposomes with special structures and functions have emerged since the first liposome injection containing doxorubicin was marketed. This review summarized the principles and research progress of Stealth liposome technology and cationic liposome technology, analyzed the structural and functional characteristics and clinical application advantages of liposome products that have been marketed from the perspective of pharmacology, introduced current research hotspots of new liposomes, and analyzed the current regulatory status of liposome injection at home and abroad, thereby providing theoretical reference for the research and development（R&D）, clinical translation and supervision of liposome injection.

Effect of Kinesio Taping on Knee Osteoarthritis: A Meta-analysis / 中国康复理论与实践

Objective:To evaluate the effect of Kinesio taping on knee osteoarthritis (KOA). Methods:The Cochrane Library, PubMed, CNKI, Web of Science and PEDro were searched from inception to November, 2018. The randomized controlled trials (RCTs) about the effect of Kinesio taping on knee osteoarthritis were collected. Two reviewers independently screened articles according to the inclusion and exclusion criteria, extracted data and evaluated the quality of the included studies. Meta-analysis was performed using RevMan 5.3. Results:A total of six RCTs were enrolled. There were significant differences in the scores of Visual Analogue Score between the intervention group and the control group (WMD = -1.28, 95%CI -2.36 to -0.20, P = 0.02). There were no significant differences in Western Ontario and McMaster Universities Osteoarthritis Index, range of motion, quadriceps femoris and hamstring muscle strength between the intervention group and the control group (P > 0.05). The other studies only adopted descriptive analysis accordingly. Conclusion:It is still uncertain in the effectiveness of Kinesio taping on knee osteoarthritis.

Analysis on the integration of generic consistency evaluation and total quality management / 中国卫生政策研究

Objective:To combine the consistency evaluation system with the total quality management,and put forward some suggestions for improving the quality of generic drugs in China.Methods:Based on the analysis of the quality of Chinese generic drugs,combined with the concept of modem process quality control,a comprehensive analysis was made on the defects of the consistency evaluation system.Results:The consistency evaluation was found to be very important for the evaluation of the results,but it is not comprehensive as the recognition is not high,and hence there are some risks in itself.As per the findings of this study,,the quality of generic drugs cannot be effectively controlled and improved at two essential points,source and the process only through the consistency evaluation.Conclusions:A good process quality management is the basis of consistency evaluation,which can compensate for the deficiency of the evaluation of the results,and reduce the risk of high input and low quality output.Therefore,it is suggested that the assessment and the total quality management standardization should be integrated and accelerated,and integrate the concept of fingerprint into the quality management system to effectively promote the quality level of Chinese generic drugs.

Analysis on the integration of generic consistency evaluation and total quality management / 中国卫生政策研究

Objective:To combine the consistency evaluation system with the total quality management,and put forward some suggestions for improving the quality of generic drugs in China.Methods:Based on the analysis of the quality of Chinese generic drugs,combined with the concept of modem process quality control,a comprehensive analysis was made on the defects of the consistency evaluation system.Results:The consistency evaluation was found to be very important for the evaluation of the results,but it is not comprehensive as the recognition is not high,and hence there are some risks in itself.As per the findings of this study,,the quality of generic drugs cannot be effectively controlled and improved at two essential points,source and the process only through the consistency evaluation.Conclusions:A good process quality management is the basis of consistency evaluation,which can compensate for the deficiency of the evaluation of the results,and reduce the risk of high input and low quality output.Therefore,it is suggested that the assessment and the total quality management standardization should be integrated and accelerated,and integrate the concept of fingerprint into the quality management system to effectively promote the quality level of Chinese generic drugs.

Influence of Chemical Drug Registration Reform on Pharmaceutical Industry in China / 中国药师

Domestic generic drug registration has a large proportion in chemical drugs with outstanding repeated registration phe-nomenon and low level innovation of enterprises. Under the above background, chemical drug registration reform kicked off. The imple-mentation of new drug registration classification, marketing authorization holder and the changes of listed drug registration documents have a huge impact on China' s pharmaceutical industry, which can promote the reformulation of domestic pharmaceutical market, en-courage R&D and innovation in enterprises and accelerate the pace towards the international market.

Comparison of stroke volume variation with pulse pressure variation as a diagnostic indicator of fluid responsiveness in mechanically ventilated critically ill patients

To compare the diagnostic accuracy of stroke volume variation [SVV] and pulse pressure variation [PPV] in studies that examined both parameters in the same patient population. Literature search was conducted in PubMed, EMBASE, CINAHL, and Google Scholar. Receiver operator characteristic [ROC] curves were examined, and summary ROC curves were plotted. The study was conducted from January to July 2013 in The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China. The meta-analysis of 19 studies published during the years 2005 and 2013 revealed a high degree of diagnostic accuracy of both SVV and PPV in predicting fluid responsiveness. The sensitivity and specificity of both the parameters were observed above 80% in a heterogeneous group of over 850 patients of which 55% responded to fluid challenge. The following values along with 95% confidence interval were noticed: SVV - sensitivity 82 [59-93%] and specificity 84 [62-95%], PPV - sensitivity 84 [62-95%] and specificity 83 [58-94%]. Area under the curve values obtained in the pooled analysis were 0.84 [0.79-0.89] for SVV, and 0.88 [0.84-0.92] for PPV. Both SVV and PPV exhibit a high degree of diagnostic accuracy in predicting the success or failure of a fluid challenge in hemodynamically unstable critically ill patients under controlled mechanical ventilation