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Objective To investigate the utilization of reproductive health services and relating factors among internal migrant population in Beijing,Shanghai and Chongqing.Methods A multi-stage cluster sampling method was adopted in this cross-sectional study,conducted in Beijing,Shanghai and Chongqing from August 2014 to August 2015.Standard methods on statistics and nonlinear canonical correlation were applied.Results Out of the 6 545 internal migrant persons,41.76％ ever used the reproductive health services in the past year.Results from the nonlinear canonical correlation analysis revealed that the utilization of reproductive health services was correlated with the demographic features (rn1 =0.28,P＜ 0.000 1) and characteristics of the population mobility (rb1 =0.21,P＜0.000 1),respectively.For the above said demographic features,canonical variable L1 which represented the demographic features was mainly determined by area,occupation and education attainment.Canonical variable M1 that reflected the utilization of reproductive health services,was mainly determined by factors as free contraceptives,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.As for the characteristics of the population mobility,canonical variable U1,which represented population mobility characteristics,was mainly determined by factors as purpose of migration,current pattern of residence and the length of annual stay in the area.Again,the canonical variable V1,reflecting the use of reproductive health services was mainly determined by factors as free contraceptives,check-up on reproductive tract infection,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.Conclusions The utilization of reproductive health services was low among the internal migrant population under study.Responsible departments for health and family planning in those cities should make internal migrants attach importance to reproductive health.
RESUMO
Objective To investigate the utilization of reproductive health services and relating factors among internal migrant population in Beijing,Shanghai and Chongqing.Methods A multi-stage cluster sampling method was adopted in this cross-sectional study,conducted in Beijing,Shanghai and Chongqing from August 2014 to August 2015.Standard methods on statistics and nonlinear canonical correlation were applied.Results Out of the 6 545 internal migrant persons,41.76％ ever used the reproductive health services in the past year.Results from the nonlinear canonical correlation analysis revealed that the utilization of reproductive health services was correlated with the demographic features (rn1 =0.28,P＜ 0.000 1) and characteristics of the population mobility (rb1 =0.21,P＜0.000 1),respectively.For the above said demographic features,canonical variable L1 which represented the demographic features was mainly determined by area,occupation and education attainment.Canonical variable M1 that reflected the utilization of reproductive health services,was mainly determined by factors as free contraceptives,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.As for the characteristics of the population mobility,canonical variable U1,which represented population mobility characteristics,was mainly determined by factors as purpose of migration,current pattern of residence and the length of annual stay in the area.Again,the canonical variable V1,reflecting the use of reproductive health services was mainly determined by factors as free contraceptives,check-up on reproductive tract infection,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.Conclusions The utilization of reproductive health services was low among the internal migrant population under study.Responsible departments for health and family planning in those cities should make internal migrants attach importance to reproductive health.
RESUMO
Objective To detect the expressions of CXCR4,Smoothened (Smo) and Patched (Ptch) in breast cancer,to analyze the clinical significance of the expression of CXCR4,and to evaluate the relationships among CXCR4,Smo and Ptch.Methods The expressions of CXCR4,Smo and Ptch from 121 cases of breast cancer specimens were detected by immunohistochemistry,and the results were analyzed.Results The positive expression rate of CXCR4 in breast cancer was 66.9％,which was positively associated with the lymph node metastasis (r =0.181,P =0.044).The positive expression rates of Smo and Ptch in breast cancer were respectively 58.9％ and 64.5％.The expressions of Smo and Ptch were positively associated with the expression of CXCR4 in breast cancer (r =0.189,P =0.036 ; r =0.230,P =0.010).Conclusion The expression of CXCR4 in breast cancer is associated with the lymph node metastasis,and it is positiviely associated with the expressions of Smo and Ptch.Patients with breast cancer who express both CXCR4 and Hedgehog signaling pathway may have a higher risk of recurrence.
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CXCL12 and its receptor CXCR4 can express in breast cancer,and are regulated by several factors in the genesis and development of breast cancer. Lots of researches have proved that CXCL12 and CXCR4 can be used as new independent prognostic makers of breast cancer.Treatment targeted for CXCR4 can be seen as a new kind of combination therapy,which may provides patients a more ideal treatment.