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1.
Artigo em Inglês | IMSEAR | ID: sea-44644

RESUMO

A 3-year-old Thai boy suffered from two histiocytoses, Rosai-Dorfman disease (RDD) and juvenile xanthogranuloma (JXG). The patient first presented with massive cervical lymphadenopathy at the age of one year. Biopsy revealed typical RDD; abnormally large CD68- and S-100 protein-positive histiocytes with occasional emperipolesis filled up the sinuses. Two years later, he developed polyuria and polydypsia. Skull film demonstrated osteolytic lesions at the occiput and left parietal region. Enlargement of the pituitary stalk was found on the magnetic resonance imaging. Despite the clinical impression of Langerhans cell histiocytosis, biopsy of the occipital lesion disclosed numerous large histiocytes with foamy cytoplasm. Several Touton giant cells with wreath-like arrangement of the nuclei were also observed. The abnormal cells expressed CD68 and factor XIIIa, but were non-reactive with S-100 protein and CD1a. Biopsy of the pituitary stalk was not performed According to the authors' literature search, this represents the first report of RDD and JXG affecting the same person.


Assuntos
Histiócitos/patologia , Histiocitose Sinusal/diagnóstico , Humanos , Lactente , Linfonodos/patologia , Masculino , Xantogranuloma Juvenil/diagnóstico
2.
Artigo em Inglês | IMSEAR | ID: sea-44096

RESUMO

OBJECTIVE: To present results of intra-operative consultation in surgical neuropathology and discuss the diagnostic guideline for squash cytology. MATERIAL AND METHOD: The intra-operative pathological diagnosis of 120 neurosurgical specimens was compared with the final histologic diagnosis. Squash preparation was used solely in 83 cases, frozen sections alone in 3 cases, and both techniques in the remaining. An algorithm for cytologic diagnosis was described. RESULTS: The intra-operative pathological diagnoses in neurosurgery were completely (83%) and partially (13%) correlated with the final results. CONCLUSIONS: Intra-operative diagnosis in surgical neuropathology is reliable. Squash cytology is highly recommended as an alternative approach.


Assuntos
Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Técnicas Citológicas , Feminino , Secções Congeladas , Humanos , Lactente , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Nervoso/patologia , Neoplasias do Sistema Nervoso/patologia
3.
Artigo em Inglês | IMSEAR | ID: sea-43739

RESUMO

Identification of cytoplasmic mucin, usually by Mayer's mucicarmine stain, is one of the criteria to diagnose adenocarcinoma. The inexpensive LacCur stain, made up of Curcuma longa (khamin-shan) and secreta of Laccifer lacca (krang) has been introduced. The aim of this study was to compare the Mayer's mucicarmine and LacCur stains in the detection of mucin material. The specimens included 17 adenocarcinomas of the stomach, 16 of the colon, 18 of the lung, 16 of the breast, and 12 of the bile duct. Squamous cell carcinoma and hepatocellular carcinoma (altogether 20 cases) were set as negative control. Like Mayer's mucicarmine, LacCur was capable of detecting of intracytoplasmic mucin in all adenocarcinomas of the stomach, colon and bile duct, and revealed mucin substance in 15/18 and 11/16 cases of specimens from the lung and breast, respectively. The negative control group showed a negative result. Although a little more time required in preparation, the LacCur stain is simple and very economical.


Assuntos
Adenocarcinoma/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Corantes/diagnóstico , Humanos , Mucinas/fisiologia , Neoplasias/diagnóstico
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