Prevalence and risk factors of cerebral small vessel disease neuroimaging markers:a Shanghai community cohort study / 中风与神经疾病杂志

@#Objective　To investigate the prevalence,age distribution and risk factors of cerebral small vessel disease (CSVD) neuroimaging markers in Shanghai elderly community population.Methods　From August 2016 to October 2019,subjects aged above 50 years and qualified for the study were enrolled from Jingan,Qingpu and Minghang districts in Shanghai.Uniformly designed clinical research forms,neuropsychological assessment,laboratory tests and MRI were performed to gather information and to analyze the prevalence,severity and distribution of lacune,white matter hyperintensity (WMH),cerebral microbleed (CMB) and perivascular space (PVS).Associations between risk factors and neuroimaging markers were analyzed by multivariate logistic regression models.Results　 Among 870 enrolled subjects who had undergone MRI,median age was 68 years and 40.2% male.Lacune,WMH (Fazekas≥2),CMB and PVS were detected in 17.6%,29.4%,27.8%,96.5% of subjects respectively.With every 10 years’increase in age,there was a 35% increase in lacune,126% increase in WMH and 51% increase in CMB.Compared with non-hypertensive subjects,hypertensive subjects had a 1.98-fold of risk detecting lacune on MRI,while a 1.64,1.91,1.45 fold of risk for WMH,CMB and PVS.ConclusionsAge and hypertension are the major risk factors for CSVD in elderly community population.Age-stratified prevalence of single imaging marker and total CSVD score may have a clinical significance in diagnosing CSVD.

Osteoporosis in patients with ischemic stroke / 国际脑血管病杂志

Most patients with ischemic stroke are accompanied by osteopenia and osteoporosis, especially in the hemiplegic side, which seriously affects the prognosis of the patients.At the same time, osteoporosis is also an independent risk factor for ischemic stroke.Among the many treatment options, rehabilitation training plays an important role in the prevention and treatment of osteoporosis.In recent years, it has gradually aroused the interest of researchers.This article reviews the relationship between osteoporosis and ischemic stroke, as well as the rehabilitation treatment of osteoporosis.