Effect of invasive and noninvasive sequential mechanical ventilation on respiratory failure of critical cor pulmonale / 中国基层医药

Objective@#To observe and analyze the clinical effects of invasive and non-invasive sequential mechanical ventilation in the treatment of respiratory failure in patients with chronic pulmonary heart disease.@*Methods@#A total of 70 patients with chronic pulmonary ill heart disease and respiratory failure admitted to the First Hospital of Shanxi Medical University from January 2018 to March 2018 were enrolled in this study.The patients were randomly divided into control group and observation group according to the digital table, with 35 cases in each group.The control group received invasive mechanical ventilation treatment.The observation group used the " pulmonary infection control window (PIC)" as the switching point of invasive ventilation and non-invasive ventilation, and invasive and non-invasive sequential mechanical ventilation were given.The clinical indicators, blood gas indicators, respiratory rate and heart rate changes of the two groups were compared.The clinical efficacy of the two groups were observed to analyze.@*Results@#The invasive mechanical ventilation time, total ventilation time and hospitalization days in the observation group were (5.16±0.83)d, (7.79±0.63)d and (8.95±0.62)d, respectively, which were significantly shorter than those in the control group [(8.42±0.91)d, (11.48±0.95)d, (14.17±0.65)d], the differences were statistically significant(t=15.659, 19.151, 34.379, all P<0.05). After treatment, the PaO2 of the observation group was significantly higher than that of the control group[(85.19±5.07)mmHg vs.(79.95±4.68)mmHg], while the PaCO2[(49.85±4.17)mmHg vs.(53.36±4.82)mmHg], respiratory rate[(24.43±3.17)times/min vs.(31.19±4.08)times/min]and heart rate[(94.43±13.36)times/min vs.(113.36±17.13)times/min] in the observation group were significantly lower than those in the control group, and the total effective rate of the observation group (91.43%) was significantly higher than that of the control group(54.29%), the differences were statistically significant(t=4.493, 3.258, 7.740, 4.338, χ2=12.209, all P<0.05).@*Conclusion@#The clinical efficacy of invasive and non-invasive sequential mechanical ventilation in the treatment of patients with respiratory failure due to chronic pulmonary heart disease is significant, which can improve the clinical symptoms of patients and reduce the time of hospitalization.

Comparison of disinfection effect of two disinfection methods on X-ray protective clothing / 中国感染控制杂志

Objective To compare the effect of GammaTM wet wipes and 75% alcohol on the disinfection of X-ray protective clothing,and provide reference for choosing rational disinfection methods.Methods 62 pieces of X-ray protective clothing were selected,30 were from operating rooms,32 from catheterization room.Protective clothing were randomly divided into trial group and control group,each had 31 pieces.Trial group disinfected clothing with GammaTM wet wipes,control group disinfected clothing with 75% alcohol,disinfection effect,drying time,and cost between both groups were compared.Results Average bacterial colony counts in trial group and control group before disinfection were 2.38 CFU/cm2 and 2.36 CFU/cm2 respectively,qualified rates were 80.64% and 83.87%respectively.Bacteria were not detected in both groups after disinfection.The average drying time in trial group was shorter than control group([352.35±9.93]s vs[676.13±10.62]s,t=123.98,P <0.01).The cost of disinfecting X-ray protective clothing in trial group was 29.60% less than control group.Conclusion Effect of GammaTM wet wipes and 75% alcohol on disinfecting X-ray protective clothing are both reliable,compared with 75% alcohol, GammaTM wet wipes are without corrosion,have shorter drying time,and save more cost.

Correlation between intracellular magnesium and expression of beta 2-adrenergic receptor mRNA in the lung of C57BL/6 asthmatic mice / 中国病理生理杂志

0.05,respectively).Plasma Mg2+,intracellular Mg2+,the beta 2-AR mRNA and protein in lung tissue in group C at 21st d and 34th d were significantly higher than those in group A at 21st d and 34th d 21st d:(0.84?0.09)mmol/L vs 0.57?0.10)mmol/L,(2.39?0.14)mmol/L vs(2.11?0.08)mmol/L,(0.75?0.09)pmol/g vs(0.59?0.06)pmol/g,(88.50?8.50)pmol/g vs(60.10?7.70)pmol/g,P

Effects of Angelica Sinensis on OLDL-induced decrease of NO release from human endothelial cells and increase of ICAM-1 expression on the surface of human endothelial cells / 中国病理生理杂志

AIM:To investigate the injurious effects of oxidized low-density(OLDL) on human endothelial cells(ECs) and protective effects of Angelica Sinensis in vitro. METHODS: The effect of OLDL on nitric oxide (NO) release from EC and intercellular adhesion molecule-1 (ICAM-1) expression on EC surface were studied, and the protective effects of Angelica Sinensis on normal and abnormal EC were investigated using cultured EC with or without OLDL and immunocytochemical staining technique. RESULTS: OLDL led to a decrease of NO release and an increase of ICAM-1 expression, which can be reversed by Angelica Sinensis and atropine can block this role of Angelica Sinensis. CONCLUSION: Angelica Sinensis has antagonistic effect on OLDL-induced decreasing of NO released from ECs and increasing of ICAM-1 expression on ECs surface . These effects of Angelica Sinensis may be exerted by the excitation of muscarinic receptor.