RESUMO
OBJECTIVE: To evaluate serum cobalamin with special reference to dyslipidemia in type 2 Diabetic subjects
STUDY DESIGN: Observational study
PLACE AND DURATION: Department of Medicine, Isra University Hospital and Consultant Clinics Hyderabad, Sindh from January 2014 to July 2014
METHODOLOGY: A sample of 107 type 2 diabetic subjects was selected according to inclusion and exclusion criteria. Cobalamin was measured on Roche Cobas e411 chemistry analyzer and blood lipoproteins by standard laboratory methods. Data was analyzed by SPSS version 21.0 using appropriate statistical test. P-value of
RESULTS: Cobalamin deficiency was noted in 51 [47.6%] of diabetics which has associated with dyslipidemia. Mean +/- SD of serum cobalamin in normal and reduced serum cobalamin groups were noted as 355+/-29.5 and 183+/-17.5 pg/ml respectively [p=0.0001]. Triglycerides, total cholesterol, HDLc, LDLc and VLDLc differed significantly in the normal and reduced cobalamin subjects
Lipoprotein sub fractions showed a negative correlation with serum cobalamin
CONCLUSION: Cobalamin deficiency is common in type 2 diabetics associated with dyslipidemia