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Objective To investigate the relationship of serum 25-hydroxyvitamin D [25(OH)D] level and blood glucose control in patients with type 2 diabetes mellitus (T2DM).Methods The clinical data of 300 pa-tients with T2DM in the hospital were analyzed retrospectively.According to the level of glycated hemoglobin (HbA1c) ,the patients were divided into the good control of blood glucose group (＜6.5%) ,the medium con-trol of blood glucose group (6.5% -7.5%) and the poor control of blood glucose group (＞7.5%).Another 44 healthy individuals with normal glucose tolerance (NGT) confirmed by oral glucose tolerance test (OGT T) were selected as normal control group.The level of 25(OH)D in each group was compared ,and the correlation between HbA1c and 25(OH)D was analyzed.Results The level of serum 25(OH)D in the poor control of blood glucose group was significantly lower than that in the good control of blood glucose group and the con-trol group ,and the difference was statistically significant (P＜0.05) ;the levels of serum 25(OH)D in the the medium and good control of blood glucose groups were significantly lower than that in the control group (P＜0.05).HbA1c was negatively correlated with 25 (OH) D level (r= -0.212 ,P=0.000).Conclusion The level of serum 25 (OH) D is related to the development of T2DM.Proper vitamin D supplementation can be used as an adjuvant therapy for T 2DM.
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Objective To discuss the effect and possibility of NIPPV in ILD combined with respiratory failure. Methods A total of 37 cases of ILD combined with respiratory failure admitted by our hospital during Feb 2004 to Oct 2007 were divided into treatment group (20 cases) and control group (17 cases). Routine pharmaceutical intervention was adopted in both groups while NIPPV was given in the patients of treatment group. The symptoms、signs and the arterial blood gases were observed and analyzed. Results Among 20 patients,3 gave up treatment , 17 patients were successfully treated with the NIPPV therapy. There were significant improvement of PaCO2、PaO2、pH and respiratory rate ,heart rate after 2h NIPPV. Conclusion NIPPV is an effective method for ILD combined with respiratory failure,which can save the patients life and decrease the complications.
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Objective To discuss the effect and feasibility of BiPAP in refractory asthma patients. Methods A total of 15 coses of refractory bronchial asthma admitted by our hospital during Feb 2003 to May 2006 were treated by BiPAP in addition to medical therapy。 The symptoms、signs and the arterial blood gases were observed and analyzed。Results Among 15 patients,2 gave up treatment,13 patients were successfully treated with the BiPAP therapy。There were significant improvement of PaCO2、PaO2、pH and respiratory rate ,heart rate after 2h BiPAP。Conclusions Ventilation in BiPAP is an effective method for refractory asthma ,which can save the patients life and decrease the complications.
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Objective To investigate the therapeutic effect of ambroxol in bleomycin-induced pulmonary fibrosis of rats.Methods Sixty Wistar rats were divided into three groups:The normal control group(group N),the model group treated with bleomycinA5(group B)and the group treated with ambroxol(group A).Pulmonary fibrosis was induced by intratracheal instillation of bleomycin.Then the rats received daily ambroxol 35mg/kg(group A),or normal saline(group B).Five rats in each group were killed on 3.7.14 and 28 days after intratracheal instillation.Histological changes of the lungs were evaluated by HE stain and Masson's trichrome stain.The levels of tumor necrosis factor-?(TNF-?)in lung homogenates were measured by radioimmunoassay.Results Pulmonary fibrosis of Group A was significantly improved as compared with that of Group B(P