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Objective To evaluate the application of optical coherence tomography (OCT) in the rat retinal light damage. Methods Albino Sprague-Dawley (SD) rats (5-8 weeks of age) were exposed to 1 000-1 400 lux of diffuse, cool, white, fluorescent light for 2, 5, and 7 d. OCT image analysis and histological measurements of the retinal thickness were performed. Animals were then sacrificed and the measured results were compared with those by histological examination. Results The sensory retinal thickness of the retina in the rats thinned progressively as the retinal degeneration was in progress. The sensory retinal thickness measured by OCT [the corresponding thickness was (179.11?12.01)?m, (159.27?12.81)?m, and (133.67?11.43)?m, respectively] was well correlated with that measured by histology [the sensory retinal thickness after exposure to the light for 2, 5, and 7 d was (144.26?9.36)?m, (116.16?11.24)?m, and (94.27?10.68)?m, respectively] (r= 0.995, P
RESUMO
Objective To investigate the morphological features of choroidal neovascularization (CNV) in central exudative chorioretinopathy (CEC) using optical coherence tomography (OCT). Methods OCT and fundus fluorescein angiography (FFA) were performed in 41 cases (43 eyes) of CEC,and the course of CEC disease was from 1 week to 10 months. Twenty seven of 43 eyes were also examined by indocyanine green angiography (ICGA). Results OCT images revealed 5 kinds of morphological features of CEC: well defined CNV(41.86 %),poorly defined CNV(30.23 %),hemorrhagic pigment epithelium detachment (PED)(16.28 %), CNV companied with serous (6.98 %) or hemorrhagic neurosensory retina detachment (4.65 %). CNV mainly showed well defined and poorly defined CNV (72.09 %).In those eyes that could clear define the CNV boundary,there were 12 eyes on FFA examination and 20 eyes on ICGA examination which defined the boundary from retinal horizontal plane, while there were 23 eyes on OCT examination which defined the boundary from retinal vertical section. Classic CNV on FFA consistently presented with well defined boundaries on OCT ,whereas non classic CNV had a variable cross sectional appearance. Conclusions The OCT morphological features of CNV in CEC is mainly well defined CNV and poorly defined CNV; OCT examination can precisely observe the retinal and choriocapillaries pathological anatomy of CEC from retinal vertical section, in making the CEC diagnosis as an important complementary examination of FFA and ICGA which observe the focus from retinal horizontal plane.