[Effect of 660nm low power laser on pain and healing in palatal donor sites; a randomized controlled clinical trial]

Free gingival graft is one of the most predictable procedures for gingival augmentation, but patient's discomfort and pain during healing period of palatal donor site is a significant concern. The aim of this study was to evaluate the effect of 660nm low power laser on pain and healing in palatal donor sites. The present split mouth randomized controlled clinical trial was performed in 12 patients at the department of periodontics of Tehran University of Medical Sciences. Patients' allocation was done by balanced block randomization [laser group and placebo group]. In laser test group [wave length: 660 nm, power: 200mW, time of irradiation: 32s] was applied immediately post-surgery and in day 1, 2, 4 and 7 after that. In the control group, laser application was done with off power mode. Evaluation of epithelialization and healing was done with H2O2 and photograph. The number of palliative pills and bleeding was recorded. Wilcoxon test was used to analyze healing during the study. Patient's pain during study was analyzed using repeated measure ANOVA. Mc Nemar test was used to analyze bleeding. Level of statistical significance was set at 0.05. Laser group showed better epithelialization [P=0.02] and healing [P=0.01] in day 14 after surgery and showed better epithelialization in day 21[P=0.05]. No statistically differences were observed between laser group and control group in terms of bleeding and medication [P=0.51], [P=1]. According to the results of this study, the low power laser can promote palatal wound healing during the second and third week after free gingival graft procedures

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

OBJECTIVES: This study aimed to assess and compare the levels of interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth. MATERIALS AND METHODS: This study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-implantitis next to healthy teeth. The crevicular fluid was collected using absorbent cones and transferred to the laboratory. Specimens were evaluated by ELISA for interleukin levels. Data were analyzed using repeated measures ANOVA and Bonferroni tests (P<0.05). RESULTS: Levels of IL-1beta in the crevicular fluid around implants with peri-implantitis were significantly higher than around healthy implants (P=0.002); the latter was significantly higher than around healthy teeth (P=0.015). A significant difference was found in the level of IL-6 in the crevicular fluid around implants with peri-implantitis and healthy implants (P=0.049) and also between implants with peri-implantitis and healthy teeth (P<0.001). CONCLUSION: Within the limitations of this study, significant differences exist in the levels of IL-1beta and IL-6 in the crevicular fluid of implants with peri-implantitis, healthy implants, and healthy teeth. More studies with larger sample sizes in different populations are necessary.