Clinical effects of reduced glutathione whitening facial mask on melisma / 中华医学美学美容杂志

Objective:To observe the effect of reduced glutathione whitening facial mask (RGWFM) on melasma.Methods:Thirty two eligible patients (31 females, 1 male, aged 28-50 years, with mean 37.5 years) were recruited to use RGWFM for 15-20 min per night. Four weeks and eight weeks later, MASI, PGA, patient self-evaluation, VISIA, ILQI and side effects were evaluated.Results:After 4 weeks` and 8 weeks` treatment, MASI index was decreased for 3.66±2.59 and 7.00±4.51 compared to the base line ( t=7.99 and 8.78 after 4 weeks and 8 weeks, P<0.05). PGA was 4.50 and 3.33 at the same time. 87.50% of the patients felt satisfied. Only one patient showed a transient burning sensation on the face. Melanin value of the VISIA was decreased for 44.24±30.52 in 4 weeks later ( t=8.19, P<0.05) and decreased for 59.95±39.47 in 8 weeks later ( t=8.59, P<0.05). 65.63% of the patients DLQI score were higher than 16 points at the beginning. The percentage was 37.50% after 8 weeks. No side effect was observed in the other patients. Conclusion:It is indicated that RGWFM is safe and has certain therapeutic effects on melasma.

Three cases of dermatomyositis presenting with inverse Gottron's papules / 中华皮肤科杂志

Three cases of dermatomyositis presenting with inverse Gottron's papules were reported.Of the 3 patients,there were 2 males and 1 female aged 43,41 and 46 years respectively,whose disease durations were 1,6,7 months respectively.Inverse Gottron's papules manifested as papules overlying the palmar aspect of the metacarpal and interphalangeal joints,which were arranged in a linear pattern in 2 cases.Of the 3 cases,1 presented with interstitial pneumonia,3 with myositis,and 2 showed negative anti-nuclear antibody test.Histopathological examination of inverse Gottron's papules in 1 case revealed focal liquefaction degeneration of basal cells and perivascular infiltration with inflammatory cells,especially lymphocytes,in the superficial dermis.The 3 patients received oral glucocorticoids and immunosuppressive agents in the early period of treatment.After 3-month treatment,clinical symptoms including muscle weakness and muscle pain were improved evidently,but no obvious improvement in inverse Gottron's papules was observed.After 1-year treatment,these papules on the palmar aspect were markedly relieved in 1 case.