Clinical-epidemiologic profile of the schistosomal myeloradiculopathy in Pernambuco, Brazil

This was a retrospective descriptive study on a series of cases of schistosomal myeloradiculopathy (SMR) and the aim was to investigate the incidence of this disease and its clinical and epidemiological characteristics in cases diagnosed at three healthcare units in Pernambuco, Brazil between 1994-2006. The data were collected by reviewing the medical records from both the neurological and paediatric outpatient clinics and wards of the Hospital Clinics, Hospital of the Restoration and Pernambuco Mother and Child Institute. To gather the data, a spinal cord schistosomiasis evaluation protocol was used. The diagnoses were based on positive epidemiological evidence of schistosomiasis, clinical findings and laboratory tests (stool parasitological examination or rectal biopsies, magnetic resonance imaging findings and cerebrospinal fluid investigations). A total of 139 cases aged between 2-83 years were found. The most important determinants of SMR were male sex (66.2 percent), contact with fresh water (91 percent), origin in endemic regions (39.5 percent), lower-limb muscle weakness (100 percent), sensory level at the lower thoracic medulla (40.3 percent), myeloradicular form (76 percent) and presence of eggs in the stool parasitological examination (48 percent). This sample indicates the need for intervention policies guided by diagnostic standardization, thereby avoiding disease under-notification.

Clinical-epidemiological profile of children with schistosomal myeloradiculopathy attended at the Instituto Materno-Infantil de Pernambuco

The most critical phase of exposure to schistosomal infection is the infancy, because of the more frequent contact with contaminated water and the immaturity of the immune system. One of the most severe presentations of this parasitosis is the involvement of the spinal cord, which prognosis is largely dependent on early diagnosis and treatment. Reports on this clinical form of schistosomiasis in children are rare in the literature. We present here the clinical-epidemiological profile of schistosomal myeloradiculopathy (SMR) from ten children who were admitted at the Instituto Materno-Infantil de Pernambuco over a five-year period. They were evaluated according to an investigation protocol. Most of these patients presented an acute neurological picture which included as the main clinical manifestations: sphincteral disorders, low back and lower limbs pain, paresthesia, lower limbs muscle weakness and absence of deep tendon reflex, and impairment of the gait. The diagnosis was presumptive in the majority of the cases. This study emphasizes the importance of considering the diagnosis of SMR in pediatric patients coming from endemic areas who present a low cord syndrome, in order to start the appropriate therapy and avoid future complications.

Estudo fotoquímico da dipirona na presença de ß e γ ciclodextrina / Photochemistry study of the dipyrone in the presence of ß and γ cyclodextrin

Neste trabalho foi estudado o efeito da irradiação por luz UV na substância ácido 1-fenil-2,3-dimetil-5-pirazolona-4-metilaminometanossulfônico (dipirona) em solução aquosa e complexada em ß e γ ciclodextrinas. Inicialmente, estudaram-se as características fotofísicas do ácido em meio aquoso, em seguida verificou-se a fotoestabilidade da substância comparando com as mesmas em cavidades de ciclodextrinas. Foi utilizado um modelo cinético de decomposição de primeira ordem para obter as constantes de decomposição aparente da dipirona em meio aquoso e em cavidades de ciclo dextrina. O encapsulamento da dipirona em ciclodextrina de uma forma geral causa uma estabilização frente a fotólise por luz UV.

In this work it was studied the effect of the irradiation UV in the substance 1-phenyl-2,3-dimethyl-5-pyrazolone-3-4-methylaminomethanosulphonic acid in aqueous solution and complexed in ß and γ cyclodextrin. Initially, it was studied the photophysics caracteristics of the acid in aqueous solution, soon afterwards verified the photostability of the substance in cyclodextrin cavities using a first order kinetic model. The encapsulament in cyclodextrin of the dipyrone in a way general cause a stabilization front the photolysis for UV light.