The correlation between the efficacy of escitalopram and the traditional Chinese medicine syndrome types of depressive disorders:a randomized controlled study / 中国药理学与毒理学杂志

OBJECTIVE To clarify whether the thera-peutic effect of escitalopram on depression patients is cor-related with traditional Chinese medicine syndrome types,and to provide a basis for more accurate drug applica-tion.METHODS A total of 235 depression patients were recruited and classified according to traditional Chinese medicine syndrome differentiation into 5 types:liver and qi stagnation(45),liver stagnation and fire transformation(43),liver qi stagnation and spleen deficiency(79),heart and spleen deficiency(20),and liver and kidney deficiency(38).All patients were treated with escitalopram(10 mg·d-1)for eight weeks.The Montgomery Depression Rating Scale(MADRS)and the 17 Hamilton Depression Rating Scale(HAMD-17)were used to score before treatment and 2,4,and 8 weeks after treatment,respectively.RESULTS Compared with before treatment,the MADRS and HAMD-17 scores and remission rates of each syn-drome type significantly improved with increasing medica-tion duration.The MADRS score relief rate of liver and kidney deficiency type was the most significant(69.3%),significantly higher than the other four syndrome types(47.5%-52.6%,P<0.05);The remission rate of HAMD-17 score was significantly higher than that of heart and spleen deficiency(50.7%vs.28.5%,P＜0.05).The remis-sion rate of HAMD-17 score in liver and qi stagnation type(52.2%)was significantly higher than that in liver stagnation and spleen deficiency type(37.0%,P＜0.01)and heart spleen deficiency type(28.5%,P＜0.05).CON-CLUSION Escitalopram may have a more significant therapeutic effect on patients with liver and kidney defi-ciency and liver stagnation depression.This study pro-vides a new approach for the more effective and accu-rate application of traditional Chinese medicine syndrome differentiation in the selection of clinical antidepressants.

Development of traditional acupuncture manipulations by professor / 中国针灸

Professor learnt from several famous acupuncturists and develops his own manipulations based on his teachers' clinical thoughts and family manipulations. "" is for cervical spondylosis and cerebrovascular diseases, etc, the description including Fengfu (GV 16), Fengchi (GB 20), Tianzhu (BL 10), Yifeng (TE 17) and Wangu (GB 12). "" is for the syndromes of hyperactivity of liver , upper heat and lower cold, and the acupoints are Taichong (LR 3), Xiangu (ST 43), Xiaxi (GB 43) and the point in the dorso-ventral boundary after fingerweb edge between the 3rd and 4th toes. "" can improve local loop and pharyngeal function with Lianquan (CV 23) and Panglianquan (Extra), 1 besides Lianquan (CV 23). The traditional manipulations of "" is for stomach and abdomen diseases with Zhongwan (CV 12) and Xiawan (CV 10) in abdomen, and professor believes that it can treat mental illness which is the same treatment for different diseases.