Research progress on the mechanism of the neurovascular coupling modulation / 中国脑血管病杂志

The neural activity and cognitive function require sophisticated regulation of blood flow in order to supply enough oxygen and glucose to the human brain. As a vital mechanism of cerebral blood flow autoregulation, neurovascular coupling (NVC) has characteristics of multiple channels and rapid response. Three physiological mechanisms in cortex, subcortex and postganglion were summarized, and the relationship between ischemia or hypoxia and NVC dysfunction was discussed in this article. In addition,the prospect of NVC mechanism study was addressed so as to provide new idea and target for treating cerebrovascular diseases.