RESUMO
Background: Skin infections are common diseases in developing countries, Skin infections due to Dermatophytes has become a significant health problem affecting children, adolescents and adults of which Dermatophytosis are of particular concern in the tropics. Dermatophytosis constitutes a group of superficial fungal infections of the epidermis, hair and nails. Objective: Dermatophytosis: North India. Methods: The study was conducted at the Department of Microbiology, Hind Institute of Medical Sciences, Barabanki, Uttar Pradesh. All samples in the form of skin and nails were collected randomly in batches under aseptically condition from both out patients & in- patients. KOH mount was done for direct exam. Culture was also done. Results: A total of 354 samples were collected of which majority were skin 341 (96.3%). Majority of the patients belonged to the age group of 21-30 (33.9%) and were males (81.4%). Groin lesion was the most common lesion (58.5%). KOH, culture and both tests positive was found in 78%, 79.7% and 66.7% samples respectively. The sensitivity and specificity of KOH was 88.7% and 44.4% respectively with positive predictive and negative predictive value of 85.5% and 41% respectively. Conclusion: In the present study, Dermatophytosis is a major problem in North Indian population & prevalence of dermatophytic infection is alarming in both rural as well as urban community in the district of Barabanki, UP.
RESUMO
The present article reveals the pharmacogstic study of Moringa concanensis Nimmo. This plant species belongs to the family Moringaceae. In the view of its medicinal importance and taxonomic confusion, pharmacognostic studies, morphological characteristics, and microscopic studies was carried out to supplement the necessary information for the systematic identification and authentication of this plant, as per WHO guidelines. With this aspect, pharmacognostic investigations of the plant were carried out and reported. This study may help in acceptable identification of this plant among several species for future references.
RESUMO
Ocimum sanctum, a well known herb in Indian medicine, possesses various therapeutic properties including healing properties and cytokine induction. Wound healing activity of cold aqueous extract of O. sanctum leaves along with its effect on tumor necrosis factor- (TNF-α) was assessed using excision model of wound repair in Wistar albino rats. After application of the O. sanctum extract, rate of epithelization with an increase in wound contraction was observed. In animals, treated with 10% O. sanctum extract in petroleum jelly, wound healing was faster as compared to control group which were treated with petroleum jelly alone but significant accelerated healing was noticed in animals which in addition to the topical application of 10% extract of O. sanctum, were prefed with 250mg/kg body weight of aqueous O. sanctum extract daily for 20 consecutive days. During wound healing phase TNF-α level was found to be up regulated by O. sanctum treatment. Early wound healing may be pronounced due to O. sanctum extract, by elevating TNF-α production.