Computerized Cardiotocography Analysis: Comparison among Several Parental Ethnic Origins / Análise de cardiotocografia computadorizada: comparação entre diversas origens étnicas

ABSTRACT Objective: We speculate that genetic racial disparity exists in fetal life and can be detected by modern computerized cardiotocography (cCTG) . Methods: This is a retrospective study comparing the results of the cCTG of pregnant patients at 37-42 weeks according to the parental ethnicity (black versus white). A cCTG was performed to analyze the variables of fetal heart rate (FHR). The cCTG variables analyzed were: percentage of signal loss; number of contractions; basal FHR; number of accelerations; number of decelerations; length of high variation episodes; short-term variability (STV); total trace duration time; and number of fetal active movements. Non-stress test (NST) parameters in the two groups were compared using the Mann-Whitney test for continuous data, and the Chi-square test for categorical variables. Results: We found a significantly lower number of active fetal movements (p 1/4 0.007) and longer periods of low variation (p 1/4 0.047) in the cCTG of black patients when compared with white patients. Conclusions: In conclusion, identifying the factors responsible for the variance in the objective analysis of CTG results is important to improve the outcomes of patients. Our study lends further evidence as to the importance of ethnicity in clinical cCTG interpretation.

RESUMO Objetivo: Especulamos que disparidade genética racial exist ana vida do feto, e que possa ser detectada por moderna cardiotocografia computadorizada (cCTG). Métodos: Estudo retrospective comparando resultados do cCTG de gestantes entre 37-42 semanas de gestação de acordo com etnicidade dos pais (negro vs. brancos). cCTG foi usado para analisar as variáveis a frequência cardíaca do feto (FHR). As variáveis abalizadas do cCTG foram o % de perda de sinal, número de contrações, basal FHR, número de acelerações, número de desacelerações, comprimento dos episódios de alta variação, viabilidade de curto prazo, tempo total de duração do rastreamento, e número de movimentos de atividade fetal. Os parâmetros do teste de não estresse (NST) em dois grupos foram comparados usando o teste de Mann-Whitney para dados contínuos e teste qui-square para variáveis categóricas. Resultados: Encontramos números significativamente mais baixos de movimentos de atividade fetal (p 1/4 0,007) e períodos mais longos de baixa variação (p 1/4 0,047) no cCTG de pacientes negros se comparados a pacientes brancos. Conclusões: Identificar fatores responsáveis pela variação na análise objetiva dos resultados de CTG é importante em resultados de pacientes que apresentam melhora. Nosso estudo fornece evidências adicionais à importância de estudos clínicos da etnicidade interpretada pelo cCTG.

Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review

Abstract Thus far, several small studies and case reports on the use of topical immunomodulators in vitiligo have been published. We undertook a comprehensive literature review, searching for studies evaluating clinical response to tacrolimus topical therapy for vitiligo. A search was performed on PubMed/Medline using the term “vitiligo”, combined with “topical” and “ointment”. Our inclusion criteria were: use of tacrolimus ointment as monotherapy to treat vitiligo. We found 29 studies from 2002 to 2014. Overall, 709 patients were treated in 29 studies. Pooling the lesions, 50% repigmentation of vitiligo patches was never achieved before 2 months of treatment, with a peak after 6 months of therapy. The best results were obtained on lesions of the cephalic region, especially the face, with tacrolimus 0.1% ointment two times daily. The percentage of non-responsive patients ranged from 0% to 14%. Treatment was generally well-tolerated; only localized adverse effects were reported. Our objective was to verify the effectiveness and safety of tacrolimus ointment monotherapy. It has good efficacy and tolerability. At present, only small trials and case series are available in the literature. Further, standardized investigations on a larger number of patients are needed.