RESUMO
Coronary disease is a frequent clinical entity which, in some cases, makes a difficult diagnostic problem. However, the very big revolution realised these last decades in both diagnostics and therapeutics, improved management of these patients. Troponins which are specific and sensitive biomarkers of myocardial damage were evaluated in several domains, especially in acute coronary diseases. We purpose to clarify diagnostic and prognostic place of these markers in acute coronary disease in order to optimize their clinical use
RESUMO
Fibrin D-dimer are the consequence of an excess of fibrinolysis. The raise of their level in coronary heart disease seems to be helpfull to enhance the diagnosis of coronary ischemia. Prospective study over 4 months, including 22 patients [16 male, 6 female] divided in 2 subgroups Group I: 10 patients investigated for stable angina Group II: 12 patients investigated for ACS without ST elevation All patients underwent fibrin D-dimer dosage and coronarography. Fibrin D-dimer levels were higher in group 11[924,5 ng/ml vs 703,9 ng/ml; p <0,0001] - In group II, 6 patients had ST depression with a level of fibrin D-dimer 879,5 ng/ml vs 969,6 ng/ml in the other 6 patients. We found a positive correlation betwen level of fibrin D-dimer and complexity of coronary lesions [1007 ng/ml in type C vs 675 ng/ml in type A lesions; p < 0,000 1]. Fibrin D-dimer seems highly implicated in coronary disease and if these results are confirmed by larger studies their routine dosage will be helpful in ACS