RESUMO
Objective: This study was conducted with the aim to investigate and compare Iranian produced and foreign oxytocin for use in induction of labor
Materials and methods: This random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. They were randomly divided into group A [n = 99] received 10 units of Syntocinon [Novartis Pharma Canada] in 500 cc Ringer lactate, and group B [n = 99] received 10 units of Oxytip [Caspian Tamin Company Iran] in 500 cc serum, who entered the study to commence induction, by signing written consent. Study variables such as induction indications [post-term, ruptured membranes, diabetes, and..], induction duration, duration of the 1[st] and the 2[nd] stages of labor, and delivery method; as well as labor outcomes like hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes [admission to NICU, oxygen and intubation] were assessed for the two groups by a trained midwife and registered in the patient's questionnaire. Data were analyzed in SPSS software using statistical tests: t-test, Chi-square, and Mann-Whitney
Results: Two groups were similar in demographic variables such as; age, BMI, parity, education. There was no significant difference regarding to obstetric and gynecologic characteristics such as: gestational age, dilatation, effacement, and fetal positioning, as well as the indication for labor induction when the study began. After intervention, variables including: induction duration, duration of the 1[st] and the 2[nd] stages of labor, delivery method; and labor outcomes such as: hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes [admission to NICU, oxygen and intubation], in the two groups, were found to be the same [P < 0.05]. Mean oxytip dosage needed was less than that of oxytocin to reach for appropriate pain [P = 0.042]
Conclusion: The two drugs in terms of labor induction and neonatal complications had similar outcomes and the locally made drug with a lower dosage appears to produce the desired outcome