Medulloblastoma in adults a clinico-pathological review and prognostic factor study of 19 cases

Out of 19 Patients diagnosed as medulloblastoma in adults, 12 were males and 7 were females. The mean age was 24 years with a range between 15 and 42 years. The main predominant features were increased intracranial pressure, headache, vomiting and papilledema. The classical histological type was encountered in 11 cases [58%] while the desmoplastic type was present in 5 cases [26%] and the pleomorphic type in 3 cases [16%]. Shunting, tumour resection partially or totally, biopsy, radiotherapy and chemotherapy were the line of treatment given to the patients. The 5 years survival for all the cases was 52.6% [50% for males and 57% for females]. Patients in older age groups tolerated the after radiation effect better and had better survival rates. Patients with a tumour with classical histological pattern had better survival as well as those in whom the tumour was totally resected, Recurrence rate was 57.9% and mainly in the posterior fossa and syinal cord metastases was found in 18.2% of the recurrent cases. Maximal tumour resection is recommended within the limits of acceptable morbidity. Post operative craniospinal irradiation is the most important step of treatment of medulloblastoma as the tumour is highly radiosensitive

effect of pyrethroids on CNS and parenchymatous organs: a toxicologic and pathologic study

Synthetic pyrethroids are widely used in our community as insecticides, they are however, toxic to humans and predominantly target the central nervous system. High doses have been noted to cause seizures in mice and other forms of damage in aquatic animals. Ezalo and other derived form pyrethrum flowers has the following chemical structure: 1- pyrethrin 25% [20 mg], 2- piperinyl butoxide [300 mg], 3- bulitrine [40 mg]. This work aimed at studying the effect of heated Ezalo on the central nervous system and parenchymatous organs of mice, exposed to the insecticide for different periods of time. Thin layer chromatography [TLC] used to detect the effect of heating on the degradation products of the insecticide and Rate Flow [R] was determined for all degradable metobolites. The results were matched against unheated Ezalo contrils