RESUMO
Administration of dietary antioxidants has been suggested to protect against the subsequent liver tissue damage. The present data to explore the hepatoprotective and antioxidant effect of anserine nitrate and /or zinc chloride against γ-irradiation induced hepatotoxicity. Healthy male albino rats were exposed to γ-irradiation from Co60 gamma cell 3500 at dose level (5.7 Gy) at a dose rate 2.67 rad/sec after 24 h and 14 days on the liver and to determine both prophylactic and therapeutic role of intraperitoneally administrated. Exposure to γ- irradiation induced a significant increase in levels of ALP, ALT and AST, while levels of glucose, total proteins, albumin, triglycerides, cholesterol, LDL-C, HDL-C, total, direct and indirect bilirubin and serum fractions were significantly decreased except for total lipids level which was almost not affected. Administration of anserine and/or zinc prior or after radiation exposure was found to offer protection against γ-irradiation induced hepatocellular damage and oxidative stress in rats, probably by exerting a protective effect against hepatocellular necrosis via its free radical scavenging and membrane stabilizing ability.