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1.
Journal of the Korean Neurological Association ; : 138-143, 2000.
Artigo em Coreano | WPRIM | ID: wpr-42431

RESUMO

BACKGROUND: Two types of word fluency tasks, namely, word generation by semantic or phonemic cues, are part of the neuropsychological evaluation of neurological patients. Cognitive mechanisms, such as strategies of memory retrieval, may differ for these two tasks. We therefore used functional magnetic resonance image (fMRI) to examine whether brain areas activated by the phonemic word fluency task may differ from those activated by the semantic word fluency task. METHODS: Semantic and phonemic word fluency tasks were administered to 112 normal subjects with two categories for each (animal and fruit names for semantic word fluency, and 'ah' and 'd' sounds for phonemic word fluency). The number and the degree of scattering of generated words were examined for the analysis of cortical activation. With another seven normal subjects, fMRI experiments were conducted while they generated words with the two types of cues (five categories for each). RESULTS: Performance in terms of number of words generated was better with semantic cues than with phonemic cues (14.15 words for semantic cues and 10.36 words for phonemic cues on the average). The same words were more commonly generated across subjects in semantic fluency tasks than in phonemic fluency. In a fMRI experiment, higher signals were observed during phonemic than in semantic word fluency tasks at the bilateral posterior-inferior temporal gyri, left premotor area, right cerebellum, and bilateral superior parietal lobules. The opposite was observed at the bilateral posterior cingulate gyri. CONCLUSIONS: The fluency tasks showed differential performance and several cortical areas showed differential activation, depending on the type of cues given for word generation. This result is consistent with the hypothesis that an automated visual imagery is adopted as word-finding strategy for semantic fluency, whereas controlled articulatory evaluation is used as a strategy for phonemic fluency.


Assuntos
Humanos , Encéfalo , Cerebelo , Sinais (Psicologia) , Frutas , Imageamento por Ressonância Magnética , Memória , Rabeprazol , Semântica
2.
Journal of the Korean Neurological Association ; : 222-227, 1999.
Artigo em Coreano | WPRIM | ID: wpr-118565

RESUMO

BACKGROUND: Functional MRI is a new neuroimaging method that detects focal blood flow change associated with neural activation. This study aimed at improving it for use as a clinical test. METHODS: We separated image reconstruction from scan acquisition as an off-line process, systematized post-processing stages, and employed SPM96 package for statistical analysis. Tasks easy enough for most neurological patients were designed for activation of motor, somatosensory, visual, and language areas. From twenty consecutive patients admitted to neurology wards, frequency of expected activation and inactivation among defined regions of interest was obtained as a measure of sensitivity and quasi-specificity. RESULTS: It took about 4 minutes for data acquisition per task condition. Thus within half an hour all four tasks were tested in cooperative patients. Post-processing took about an hour per task condition, using PC-based analysis packages. Sensitivity and quasi-specificity were about 70% and 90%, respectively. CONCLUSIONS: Our newly developed method shortened the time for fMRI acquisition and systematized post-scan analysis. Data obtained from patients showed acceptable reliability for clinical use, but further research and improvement should be necessary.


Assuntos
Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Neuroimagem , Neurologia
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