Surgical complications in 1,049 cases of cervical intrafascial semm hysterectomy (CISH) / 대한산부인과학회지

OBJECTIVE: The aim of this study is to evaluate the complication rate of Cervical Intrafascial Semm Hysterectomy (CISH). METHODS: 1,049 CISH were carried out from April 1997 to August 2006 at our department. Retrospective review of medical records was performed to investigate the incidence and the type of complications during CISH procedures. RESULTS: 281 (26.79%) of the patients had a history of laparotomy. Overall 98 (9.34%) complications occurred. There were 30 (2.86%) transfusion, 19 (1.81%) transient bladder dysfunction, 12 (1.14%) cervical stump bleeding, 11 (1.05%) abdominal wound infection or disruption, 7 (0.67%) paralytic ileus, 6 (0.57%) incisional hernia, 4 (0.38%) cervical stump infection, 2 (0.19%) ureter injuries and 2 (0.19%) bladder injuries. And there were one case of transient peroneal nerve palsy, trocar site bleeding, trocar site endometriosis, foreign body in bladder and pelvic abscess. CONCLUSIONS: CISH procedure lessens the risk of ureteral and bladder injury, but this procedure increases the risk of cervical stump bleeding and infection morbidity.

Expressions of cyclooxygenase-2 and P-glycoprotein in epithelial ovarian carcinomas / 대한산부인과학회지

OBJECTIVES: The purpose of this study was to evaluate expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in ovarian epithelial carcinomas, to find out the correlations between their expression and clinicopathological parameters, and to evaluate the response to treatment and clinical outcome according to their expression. METHODS: Immunohistochemical studies of COX-2 and P-gp were carried out in 64 cases that were treated with ovarian epithelial carcinomas at Department of Obstetrics and Gynecology, Korea University Hospital, Korea University from 1996 to 2005. RESULTS: COX-2 over-expression was detected in 20 (31.2%) cases and was significantly higher in non-responder than responder to chemotherapy (56.2% versus 22.9%, respectively; P=0.012). The patients of COX-2 overexpression showed shorter overall survival (P<0.001). Over-expression of P-gp was detected in 15 (23.4%) cases was significantly higher in non-responder than responder to chemotherapy (56.2% versus 12.5%, respectively; P<0.001). The patients of P-gp overexpression showed shorter overall survival (P= 0.042). CONCLUSION: COX-2 and P-gp overexpression could provide additional information to identify ovarian carcinoma patients with poor chance of response to chemotherapy.