Prevalence of cardiovascular risk factors in psoriasis patients

To assess the prevalence of cardiovascular disease [CVD] risk factors in patients with psoriasis. Patients and methods The study group included seventy-three patients with psoriasis aged 20-50 years and an equally sized sex and age matched control group. CVD risk factors including diabetes mellitus [DM], hypertension [HTN], dyslipidemia, obesity and smoking history were assessed. Results Most of the CVD risk factors were more prevalent in psoriasis patients versus controls. The risk factors with a positive correlation included: DM [OR: 4.96, CI: 1.165-14.89], HTN [OR:3.16, CI:1.01-9.81], hypertriglyceridemia [OR:3.91, CI: 1.51-10.09], obesity [OR: 2.74, CI: 1.34-5.60] and increased level of low density lipoprotein-cholesterol [LDL-C] [OR:1.77, CI:1.08-1.73]. No significant differences were found between two groups for high density lipoprotein-cholesterol [HDL-C] and cigarette smoking. Conclusion CVD risk factors were more common in this young and middle aged psoriasis patients group, so early screening test for CVD risk factors is recommended in this group of patients

Effect of vitiligo on self reported quality of life in Southern part of Iran

Vitiligo is a chronic pigmentary disorder of the skin. Although not life threatening, it has considerable effects on the psychological well-being of patients. It has been suggested that vitiligo patients suffer from low self-esteem and poor body image which may cause a lower level of quality of life. To evaluate the effect of vitiligo on the self reported quality of life among inhabitants of south part of Iran. One hundred and twenty four patients, above 16 years of age, from dermatology clinics and phototherapy centers were included in the study from 2008 to 2009. A valid translated version of the self-reported Dermatology Life Quality Index [DLQI] with 10 questions was completed by the subjects. The questionnaire scored the subjects from 0 to 30. Demographic variables such as age, gender, and disease related characteristics were recorded in the data sheet forms. On average, patients were 27.8 +/- 10.9 years old. Around 55% were females. The overall mean DLQI score was 9.09 +/- 6.18. The DLQI mean score was 8.78 and 9.46 in women and men, respectively [p=0.54]. DLQI score did not significantly vary among different types of disease, age and marital status groups. Although the relationship between the duration of disease was not significantly related with DLQI [r=0.03, p=0.74], the percentage of body affected by vitiligo was related with DLQI significantly [r=0.19, p=0.03]. The highest individual mean scores were found for Q2 [feeling], Q8 [interpersonal relationship] and Q5 [social life and leisure activities]. This study indicates that vitiligo can impair a patient's quality of life and have a marked psychological impact. On an average, the quality of life decreased around 70% [score 9 out of 30] in such patients. The only significant predictor for quality score was the percentage of body affected by vitiligo. Surprisingly, both men and women express comparable level of quality of life

Evaluation of quality of life in patients with psoriasis

Psoriasis is a chronic, relapsing disease of the skin with psychological and somatic impacts that leads to substantial effects on the quality of life. The aim of this study was to determine the quality of life in psoriatic patients. This cross-sectional study was conducted on 97 psoriatic patients in dermatology and PUVA clinic in Afzalipour hospital in Kerman from March 2009 to March 2010. Quality of life and disease severity were Dermatology Life Quality Index [DLQI] and Psoriasis Area Severity Index [PASI]. Data analysis was done through conducting, chi-square and one-way AVONA tests and P<0.05 was considered as significant. 55.7% of patients were male and mean age of them was 35.3 years [range: 16-75 years]. Psoriasis vulgaris was the most common type [76.3%], and arthropathy was seen in 3.1% of patients .The mean duration of the disease was 21 months [range: 11 months-30 years].The mean of DLQI score was 14.1 [range: 1-29] and mean PASI score was 18.6 [range: 0.6-66.6]. DLOI score correlated with severity of disease [PASI], marital status, and type of the disease [P<0.05]. Psoriasis has a severe negative impact on the quality of life of the patients. Therefore, supportive social and spiritual efforts are necessary to decrease these effects

Prevalence of polycystic ovary syndrome in women with acne: hormone profiles and clinical findings

Polycystic ovary syndrome [PCOS] is the most common endocrine disorder and is the leading cause of hyperandrogenemia in women. Acne vulgaris is also a common cutaneous manifestation of hyperandrogenism. To determine the prevalence of PCOS in patients with acne and its associated factors with regard to the clinical and paraclinical findings. In this cross-sectional study, 118 women with acne referred to various clinics of dermatology were enrolled. A clinical examination was followed by a laboratory examination, including hormone profile and ovarian sonography. Confirmation of PCOS was based on the diagnostic criteria of the National Institute of Health [NIH] and the sonographic findings. The subjects were 14-38 years old. PCOS was diagnosed in 57 [48.3%] patients by sonography methods, while, 71 [60.2%] patients were diagnosed as PCOS cases based on the NIH criteria. Around 54% of the patients complained of hirsutism and 37% of them suffered from menstrual disturbances. PCOS versus non-PCOS had profiles of prolactin [19.36 +/- 11.96 ng/ml vs. 17.31 +/- 9.29 ng/ml], testosterone [0.80 +/- 0.57 pg/ml vs. 0.93 +/- 0.98 pg/ml], and dehydroepiandrosterone levels [2.48 +/- 1.98 microg/dl vs. 1.97 +/- 1.02 microg/dl], which were not statistically different [p>0.05]. The luteinizing hormone to follicular stimulating hormone ratio was significantly higher in PCOS [p=0.01]. According to the findings of this study, PCOS is a common disorder among women with acne. Although PCOS was expected to correspond with a specific hormonal profile, our study showed that most of the PCOS patients had normal levels of tested hormones. Therefore, we recommend that sonographic evaluation be one of the core examinations in the diagnosis of PCOS in women having acne

Report of a four-year-old boy with progeria without total alopecia

Hutchinson-Gilford progeria syndrome is an extremely rare condition with features of premature and accelerated ageing. The pattern of inheritance is unclear, although autosomal dominant mutations have been proposed. The disease presentation is usually in infancy and early childhood with a characteristic phenotype of short stature, abnormal skin and nail, beaked nose, loss of subcutaneous fat, failure to thrive, varying degrees of alopecia and premature graying of hair and prominent scalp veins. Laboratory and pathological findings are not characteristic and death results from cardiovascular abnormalities usually in the second decade of life in the majority of cases. We report a four-year-old boy who came to our hospital with history of mottled pigmentation of skin and abnormal pacies. Due to clinical features and pathological data, the case was diagnosed as Hutchinson Gilford progeria syndrome