A Therapeutic Trial of Tubercin-3 in Wart Diseases / 대한피부과학회지

Human wart diseases are benign skin tumors caused by viruses of the papova group which usually affect children and almost always regress until adulthood. Various therapeutic modalities have been tried for the treatment of warts, however there is no single satisfactory method and the clinical course as well as the prognosis is always variable. The spontaneous regression of warts may represent an increase in the activity of host immune responses. Recent studies have tended to confirm that serum antiviral antihodies and cellular immune responses occur in relation to regression of warts, but there is no convincing evidence of a correlation between the appmrance of immune responses and resolution of the warts. BCG and some of similar extra,cts have becn known to be capable of initiating a wide range of non-specific immune reactions to cancerous diseases. The aim of the present investigation has been to study no-specific irnmune response of Tubercin-3 in patients with svarts, based on the findings that RCG and some of similar extracts were found to be a potent reticuloendothelial stimulant. Taventy casee attending a, dermatolo-ical out-ptient department consists of eight verrua plana juvenilis, seven verruca vulgaris, one verruca plxntaris and four molluscurn contagiosum were trezted with Tubercin-R. The results revealed complete cure in six(37. 5.) and clinical improvemeat in nine. (56. %) of sixteen cases of various warts, and one of four czses of molluscum contagiosurn showed a slight decrea,se in size and nu!nber of the lesions. There is no eviclence of a correlation among the age of patient, type of verruca and therapeutic effect. On the basis of our findings, we can state that non-specific immune response of BCG .and some of similar extracts may be facilitate the involution of warts. The relationship of thes immune respons to the involution of warts clezrly require further study.

A Case of Sebaceous Epithelioma Arised within a Nevus Sebaceus of Jadassohn / 대한피부과학회지

A clinical and histological study of typical sebaceous epithelioma (basal cell epitheioma with sebaceous differentiation) developed secondarily in lesions of nevus sebaceus of Jadassohn is presented. The patient was 42 years old male. The sebaceous epithelioma tends to have about the same clinical characteristics as undifferentiated basal cell epithelioma but it is more often a yellow color. Sebaceous epitheliova may arise from nevus sebaceus and it is preursor of undifferentiated basal ce]1 epithelioma. Histological]y, the preparation showed massive development of sebaceous gland, papillomatous epidermal hyperplasia and maturation of apocrine glands. The tumor cell nests were mostly composed of large sheets of irregularly shaped cells in palisading pattern at the periphery. There were Iarge number of cells with vacuolated cytoplasm resembling sebaceous cell in certain part of the tumor cell masses and several keratin pearls. Diagnosis confirmed by clinical appearance and histological picture. These lesions could be treated sucessfully by wide excision.

Clinical Effects of Lidex(R) Cream / 대한피부과학회지

Lidex' cream (Fluocinonide 0.05% in FAPG base) is a new fluorina,ted topical corticosteroid, and its clinical effect was assessed by applying topically three to four times daily to the lesions of 50 patients with a variety of inflamrnatory skin condi- tions. The results revealed excellent effect in 16 patients, moderate effect in 23 patients, slight improvement in 9 patients, and no effect in 2 patients. No unfavorable side effects were noted except blanching. The findings suggest that fluocinonide is an excelIent addition to the topical corticosteroid agents that are available for clinical use at the present time.

Treatment of Hyperpigmented Disease with 4-Isopropylcatechol / 대한피부과학회지

Disfiguring hyperpigmentation of the exposed areas may have impartant and lasting effects on the emotional well-being of the patient. And many attempts to treat areas of hyperpigmentation have been earried out, but all of them are not very successful. Recently 4-isopropylcatechol has been known to inhibit melanin pigmentation with a selective action on melanocytes either destroying or inactivating the melanocytes experimentally. There is no report on its clinical trial till now. In this study, 1% 4-isopropylcatechol cream was topieally applied to the hyperpigmented lesions of 29 patieots of melasma, freckle, and cafe-au-lait spot. The bleaching effect on meiasmas was very satisfactory in all patients but coantact dermatltis in 3 patients and reticular hyperpigmentation with areas of depigmented spots in one patient were developed as the side effects of the drug. Freckle and cafe-au-Iait spots were not bleached.

Studies on the inflammatory Nodular Diseases of the Legs / 대한피부과학회지

Inflammatory nodular vascular diseases of the legs have been classified as severah distinctive entities based on their minor clinical and pathological variations. They have so many common features which often make the differential diagnosis difficult or impossihIe that reevaluation of these diseases is one of the important problems in the dermatologic field. The author studied the clinical and pathological relationship of those diseases in 86 patients including 70 cases of erythema nodosum, 7 of erythema induratum, 3 of panniculitis, and 6 of nodular vasculitis. The results are as follows; l. Erythema nodosum, erythema induratum and nodular vasculitis are most common. In the spring and patient are most often in their twenties. 2. Common to all, females are more commonly affected than males. 3.Erythema nodosum, erythema induratum and nodular vasculitis reveal no definite difference in their clinical pictures and laboratory findings. 4. Erythema nodosum, erythema induratum and nodular vasculitis are founded to be assoeiated with mostly streptococcal infection and/or tuberculosis; panniculitis is associated mainly with streptococcal infection.5. In histopathological findings, tubercle formation and caseation necrosis are more marked in erythema induratum than in erythema nodosum and nodular vasculitis. 6. The panniculitis is characterized by inflammation of the small sized vessels in. subcutaneous tissues; Nodular vasculitis reveals its main lesion in the large sized. Vessels of lower dermis. In erythema nodosum and erythema induratum, small. And medium-sized vessels are involved in subcutaneous tissue.

Clinical Effects of Combined Treatment of Prednisolone and Psoralen on Vitiligo / 대한피부과학회지

Although the psoralen therapy has been used extensively on vitligo since the : introduction by El-Mofty on 1948, the result has not been satisfactory. Recent investigations showed that the autoimmune mechanism might be the causative factor to the development of vitiligo, and the use of steroid might be expected to be beneficial in the treatment of this disorder. Authors tried the combined treatment of prednisolone and psoralen on vitiligo and the results obtained are as follows; 1. Repigmentations began to develop from injected area of prednisolone as well as frorn hair follicles and peripheral area of the lesions. 2. More satisiactory responses were obtained on the widespread and symmetrical lesions of shorter duration than on the lesions of localized and long duration.

Clinical Trials of Tavegyl in Dermatologic Field / 대한피부과학회지

Clinical trials were done to obtain ifnormation on the clinical efficacy, tolerance and side effects of a new antihistarnine, Mecloprodine(Tavegyl), in various skin disordetrs. A total of 48 patients suffered from various skin disorders as urticaria, eczema etc. v ere treated with 2mg. daily for 3 days to 15 days according to state of disorders. The results are as follows. 1. Improvement was noticed in 79.2% of total patients(38/48). 2. Tavegyl was efiective in all 8 cases of acute urticaria and most cases(7/8) of urticaria factitia. 3. Among 19 cases of chronic urticaria, improvement was noticed in 13 cases(68. 49). Improvement was alsa noticed in all 6 cases of eczema. 5. Drowsiness and weakness cccurred in 6.2% of cases(3/48).

Subcorneal pustular Dermatosis: Report of a Case / 대한피부과학회지

A case of typieal subcorneal pustular derrnatosis in 16-year-old female was presented. She failed to respond to oral administration of sulfone, however responded favorably to prednisolone.

Ehlers - Danlos Syndrome Occured in Two Generations / 대한피부과학회지

Ehlers-Danlos syndrome, a heritable disorder of connective tissue by autosomal dominant mode, is very rare disease in this country. Authors described a typical case in 39 years old woman who had a daughter of 6 years old also affectect by this disorder. The patient had the characteristic hyperelasticity of the skin and hyperextensibility of the jonts especially at metacarpophalangeal joint of the hands. She also revealed hyperterolism and aortic insufficiency on X-ray and E.C.G. examination.