RESUMO
The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a significant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addition, the splenium of corpus callosum (posterior fifth) showed a significant decrease of fiber diameters in the myelinated fibers without changing density. There was also a significant decrease in diameter and a significant increase in density of unmyelinated fibers. Measurements of perimeter's fractal dimensions from sagittal sections of the brain and corpus callosum did not show significant differences between malnourished and control animals. These findings indicate that cortico-cortical connections are vulnerable to the prenatal malnutrition, and suggest this may affect interhemispheric conduction velocity, particulary in visual connections (splenium).
Assuntos
Animais , Feminino , Masculino , Gravidez , Ratos , Corpo Caloso/anatomia & histologia , Desnutrição/patologia , Fibras Nervosas/ultraestrutura , Efeitos Tardios da Exposição Pré-Natal/patologia , Peso Corporal/fisiologia , Grupos Controle , Corpo Caloso/fisiologia , Desnutrição/fisiopatologia , Fibras Nervosas Mielinizadas/ultraestrutura , Efeitos Tardios da Exposição Pré-Natal/fisiopatologia , Ratos Sprague-DawleyRESUMO
La desnutrición prenatal altera las propiedades dinámicas de las sinapsis axodendríticas del APF. Puesto que estas sinapsis constituyen parte del sustrato anatómico/neuroquímico que se encuentra en la base de los procesos cognitivos, su disfunción puede tener un correlato con las alteraciones conductuales y de aprendizaje encontrados en desnutrición experimental