RESUMO
Prerequis: The serum markers ASCA and pANCA can help the clinician in certain difficult situtations of colites in IBD
The aim of this study was to determien the sensitivity and the specificity of each one of these markers and to establish the characteristics of the positive patients for each one
Methods: We included patients having a Crohn's disease [CD] or an ulcerative colitis [UC]. These patients was compared to a control group
Results: 80 CD patients with an average age of 35.62 years, 25 UC cases with an average age of 34.92 years and 79 healthy subjects with an average age of 34.2 years were included. The ASCA were dected in 33.8% of CD cases, 8% of UC cases of RCH and 2.5% of contro group [p<000.1]. The pANCA were detected in 48% of UC cases, 27.5% of CD patients and 1.3% of controls [<000.1]. The sensitivity and the specificity of the ASCA and the pANCA for the diagnosis respectively of CD and UC were 33.8%, 97.5% and of 48%, 97.8%. During the CD, the positivity of the ASCA was significantly associated with ileal location [p=0.001], with the stenosant and/or fistulisant phenotype of the disease [p=0.006], the young age at the time of the diagnosis of the CD [p=0.067] and at a greater frequency of surgical treatment [p=00.7]. The pANCA were more frequently found in colic location of CD [p=0.09]. During UC, the positivity of the pANCA was not associated with the sex, age, location of the disease, medical treatment nor chirurgical treatment
Conclusion: The ASCA and pANCA are useful during some clinical situations such as differentiation between IBD others colitis and to distinguish CD from UC