The Mitigating Effect of Jatropha curcas L. Latex against Genotoxicity Induced by Doxorubicin

Jatropha curcas (Euphorbiaceae) is a multiple purpose lacticiferous plant with potential for biodiesel production and medicinal uses. There is in the literature different analyses about the toxic and cytogenotoxic effects of J. curcas extracts, but few information about latex toxicity. In addition, few models were employed to evaluate the toxicity response to J. curcas latex, and the toxicity in in vivo mammal’s model has not been tested yet. The cytotoxic, mutagenic and antimutagenic potential of J. curcas latex were investigated using mouse bone marrow erythrocytes. The results indicated a cytotoxic and mutagenic potential of this latex to mammalian cells. But, when J. curcas latex was co-administrated with doxorubicin (DXR – chemotherapy medication), a reduction in the number of micronuclei was observed, indicating an interaction between J. curcas latex and DXR. The interaction of latex with DXR can cause a reduction in the activity of this drug and impair the treatment of its users. Moreover, there is a lack of data on herb–drug interactions, what should be more investigated to safeguard the wellbeing of patients.

Análise e interpretação dos níveis de actividade física de crianças: um tutorial baseado na modelação hierárquica ou multinível / Analysis and interpretation of physical activity levels in children: a tutorial based on hierarchical or multilevel modelling

Este tutorial pretende apresentar, de modo didáctico, uma forma alternativa de análise de dados sobre os níveisde actividade física de crianças a partir da modelação hierárquica ou multinível. São mencionadas as diferentes etapas damodelação, os resultados são interpretados com base nos output´s do software utilizado - o HLM 6.02. Em cada etapa do percurso são lançadas as hipóteses mais importantes em grau de complexidade crescente. A sua importância é referida a partir dos resultados disponíveis...

This tutorial aims at a didactical presentation of an alternative approach to analyse physical activity data of children based on hierarchical or multilevel modelling. We present the basic steps of the data analysis, interpreting all relevant outputfrom the chosen software - HLM 6.02. Each step is duly presented and explained, going from simple hypothesis to more complex ones. Their relevancy is presented in terms of the available results...