RESUMO
Objective: To investigate the clinical efficacy of Wei Chang An Pills combined with Artemether Injection in the treatment of malaria (gastrointestinal type). Methods: Patients (253 cases) with malaria (gastrointestinal type) in Hospital de L'amitie Sino-Congolaise in The Republic of Congo from July 2013 to December 2014 were randomly divided into control and treatment groups. Patients (130 cases) in the treatment group were im administered with Artemether Injection and po administered with Wei Chang An Pills. Patients (123 cases) in the control group were im administered with Artemether Injection and po administered with Vitamin B6 Tablets. Patients in both two groups were treated for 7 d. After the treatment, the efficacy was evaluated, and the improvement of nausea, vomiting, abdominal pain, and diarrhea was observed, white blood cells and red blood cells in feces were simultaneously detected, numbers of plasmodium in peripheral blood were counted. Results: After the treatment for 5 d, the clinical symptoms of all the patients (130 cases) in the treatment group disappeared. After the treatment for 7 d, clinical symptoms of patients (87 cases) in the control group disappeared, and there were differences between two groups (P < 0.05). Compared to the control group, white blood cells and red blood cells in feces of patients in the treatment group decreased significantly (P < 0.05). The number of plasmodium in peripheral blood of patients in the treatment group was significantly decreased. Conclusion: Wei Chang An Pills combined with Artemether Injection have the good effect in the treatment of malaria (gastrointestinal type), and can improve the clinical symptoms of patients and shorten the course, and also have anti-malarial function.
RESUMO
Objective: To study the prevention and rehabilitation of Shengxue Pills on liver, spleen, bone marrow cells, peripheral blood lymphocyte of mice injured by low-dose radiation and their mechanisms. Methods: Mice were randomly divided into five groups: control, Shengxue Pills prevention, Shengxue Pills rehabilitation, model 1 (corresponding to rehabilitation), and model 2 (corresponding to prevention) groups. Using the ELISA method to detect the activity of hydroxyl radical, superoxide anion radical, and ornithine decarboxylase (ODC) in liver and spleen cells. The bone marrow cells and peripheral lymphocyte micronucleus rate were observed under high power lens. Results: Compared with control group, the amounts of hydroxyl radical and superoxide anion radical in the two model groups were obviously increased. Compared with the corresponding model groups, the above indexes in prevention group and rehabilitation group were significantly decreased. Compared with the control group, the activity of ODC in mice of the two model groups was obviously enhanced, but bone marrow cells and peripheral lymphocyte micronucleus rate were increased. Compared with the corresponding model groups, the activity of ODC in mice of prevention and rehabilitation groups was weakened, and bone marrow cells and peripheral lymphocyte micronucleus rate were decreased. But each index of spleen cells showed no significant difference. Conclusion: Shengxue Pills could effectively prevent and rehabilitate the damage in liver cells, peripheral blood lymphocytes, and bone marrow cells of mice injured by low-dose radiation.