A case of inguinal endometriosis in the absence of previous gynecologic surgery / 대한산부인과학회지

Endometriosis is a common gynecologic disease, it occur not only pelvic organ but also anywhere in human body. However inguinal endometriosis is a very rare condition, its incidence is 0.4% of entire endometriosis. Most of inguinal endometriosis are found as inguinal masses in women in 30s and 40s who have history of gynecologic surgery. Majority of the cases are accompanied with pelvic endometriosis. Authors report a case of inguinal endometriosis in patients who has no history of gynecological surgery.

A Case of Advanced Gastric Cancer Diagnosed by Endoscopy Performed in the Second Trimester due to Persistent Nausea and Vomiting / 대한주산의학회잡지

Gastric cancer is rarely associated with pregnancy and its incidence is reported to be 0.1%. The dilemma in the treatment of this rare occasion is that it is usually diagnosed at an advanced stage. The most common reason for delayed diagnosis is that early symptoms of gastric cancer, such as nausea, vomiting and epigastric discomfort, are nonspecific and usually misinterpreted as those related to pregnancy. Clinicians' reluctance to request diagnostic studies is another reason for delayed diagnosis. So these make the prognosis much worse. We must consider the rare possibility of gastric cancer in case of persistent nausea and vomiting. We report a case of advanced gastric cancer diagnosed by gastroscopic examination performed in the second trimester because of persistent nausea and vomiting.

The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer / 대한산부인과학회지

OBJECTIVE: To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer. METHODS: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining. RESULTS: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413). CONCLUSION: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.

Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer / 부인종양

OBJECTIVE: To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining. METHODS: Tissue samples (n=72) were collected after staging operation between 1998 and 2004. RESULTS: In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI). CONCLUSION: We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.