RESUMO
Cardioprotective effect of ethanolic extract of Terminalia chebula fruits (500 mg/kg body wt) was examined in isoproterenol (200 mg/kg body wt) induced myocardial damage in rats. In isoproterenol administered rats, the level of lipid peroxides increased significantly in the serum and heart. A significant decrease was observed in the activity of the myocardial marker enzymes with a concomitant increase in their activity in serum. Histopathological examination was carried out to confirm the myocardial necrosis. T. chebula extract pretreatment was found to ameliorate the effect of isoproterenol on lipid peroxide formation and retained the activities of the diagnostic marker enzymes.
Assuntos
Agonistas Adrenérgicos beta/toxicidade , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Frutas/química , Coração/efeitos dos fármacos , Isoproterenol/toxicidade , L-Lactato Desidrogenase/sangue , Peróxidos Lipídicos/sangue , Infarto do Miocárdio/induzido quimicamente , Necrose , Fitoterapia , Extratos Vegetais/uso terapêutico , Ratos , Terminalia/químicaRESUMO
Antioxidant role of Arogh in isoproterenol induced myocardial infarction in rats has been studied. The activity of heart tissue antioxidants like glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly decreased in isoproterenol administered group. The activity of ceruloplasmin and levels of glutathione, vitamins E and C were also found to be substantially decreased in serum with a concomitant rise in lipid peroxide levels after isoproterenol exposure to rats. The synergistic effect of Arogh pretreatment, significantly suppressed the alterations induced by isoproterenol alone in rats.