P53 Expression in benign, dysplastic and malignant oral squamous epithelial lesions

To observe the frequency of benign, dysplastic and malignant oral squamous epithelial lesions and to calculate p53 expression in these lesions. This was a retrospective study. All the oral biopsies received during the period 1st July 2000 to 30th June 2005 were reviewed. Histopathological parameters were noted. Immunohistochemical staining was performed to see the p53 expression in these lesions. There was a single case of benign lesion/papilloma, which showed basal p53 immunoexpression. The dysplastic lesions account for 10 cases. p53 immunoexpression was positive in 75% cases of the dysplastic lesions. Squamous cell carcnoma was found to be the commonest malignant oral epithelial lesions accounting for 412 cases. Malignancy grading was also performed which showed maximum number of cases between score of 9-12. p53 immunoexpression was found positive in 76.8% cases of squamous cell carcinoma. Squamous Cell Carcinoma [SCC] was found to be the commonest oral malignant epithelial lesion. p53 immunoexpression was found in 76.8% cases of oral squamous cell carcinoma. The p53 immunopositivity was increasing as the grade score was rising but decreasing further as the tumor became poorly differentiated. Combining histological analysis with p53 immunoexpression, evaluation of dysplastic lesions could be improved

Gestational trophoblastic disease experience at the basic medical sciences institute, JPMC, Karachi

The study was carried out to evaluate the frequency and types of gestational trophoblastic diseases [GTD] in endometrial and hysterectomy specimen received for histopathology examination. Department of Pathology, Basic Medical Sciences institute, Jinnah Post Graduate Medical Center [JPMC] Karachi. One thousand three hundred forty two cases of endometrial curettage [EC] and 1832 hysterectomy specimens were examined. Out of 1342 cases of endometrial curettage [EC] 242 cases of hydatidiform mole and 5 cases of choriocarcinoma were seen, whereas out of 1832 hysterectomy specimens, 9 cases of invasive mole were seen. Hydatidiform mole was found to be the commonest gestational trophoblastic disease