RESUMO
Objective To investigate the hospital acquired infections in the Traditional Chinese Medicine Division of Nanshan People's Hospital, Shenzhen so to improve the infection control. Method The hospital acquired infection cases in the Traditional Chinese Medicine division during the time from May 1,2006 to May 1, 2007 were reviewed. The risk factors of acquired infections in hospital for Ankylosing Spondylitis patients were analysed and summed up. Result The hospital infection rate was 5.1% (22/435), while the total hospital acquired infection rate in the hospital was 3.2% (957/29 846). Among the 22 patients, 6 cases were ankylosing spondylitis cases. The rate of hospital acquired infection in ankylosing spondylitis patients in the division was as high as 25.0% (6/24) in contrast to the rate of zero in other wards. Further analysis showed that taking cellulotoxic drugs was the main risk factor of hospital acquired infection in ankylosing spondylitis patients (P <0.01). Conclusion The patients treated with cellulotoxic drugs should be monitored for hospital acquired infection so as enhance the early control.
RESUMO
OBJECTIVE : To prepare the sustained release tablets of salbutamol sulfate,and to establish the method of quality control.METHODS: The sustained release tablets were prepared by using salbutamol sulfate, lactose, sodium carboxymethyl starch, HPMC, EC, and MCC and coated with enteric soluble acrylic resin.HPLC was employed to determine the content of salbutamol sulfate, while at the same time dissolution grade in vitro was determined, and stability was investigated.RESULTS: : The detectable concentration of salbutamol sulfate showed a good linear correlation with peak area in the range of 1.25～20.00?g/ml.The average recovery of salbutamol sulfate was 98.60% (RSD=0.66%).The prepared tablets showed a timing release 5 hours after administration.No evident changes in dissolution were found in all tests of stability.CONCLUSION: The formulation of the preparation is reasonable; the preparation technique is simple and feasible, and the quality is stable and controllable.