Impact of Demonstration of Nutrition Garden for Year-round Nutrition Security in Farm Families of Prakasam District, Andhra Pradesh, India

Malnutrition is a nationwide issue that is quickly getting worse. Malnutrition hinders social and mental development in addition to slowing down a child's growth and development and also pregnant, lactating women, adolescent girls. It also increases the likelihood and length of illness.Long-term consequences of under nutrition include cognitive and development deficiencies as well as lowered infection resistance.With the purpose of evaluating the nutritional security of farm households, the current study seeks to comprehend the value of nutrition gardens. The current study was carried out in Prakasam district, Andhra Pradesh, consecutively for two years.From the recipients of the KVK front line demonstration programme on nutrition security, 90 respondents (50 with nutrition gardens and 50 without) were chosen at random.The 200 m2 area wasfound appropriate for the medium family group of five members. Among the vegetables cultivated in nutria garden, highest benefit was obtained from the cultivation of okra (1: 2.38) followed by spinach (1: 1.48). There was increase of 90g of consumption of vegetables after nutri garden. After nutri garden the normal weight percentage of individuals was 51.1% and underweight individuals were 35.5%.The nutritional garden encouraged families to include freshly picked vegetables in their daily diets, which helped to improve their families' nutritional condition.

Homology modeling and drug designing of 18KDA antigen in mycobacterium leprae.

Most of the antigens of Mycobacterium leprae that have been identified are members of stress protein families. 18kDa antigen of M. leprae is an important antigen in the immune response to leprosy. This protein antigen of M. leprae is related to the family of small heat shock protein. To predict the structure of 18kDa antigen and to understand the mechanisms of inhibitors interaction, a threedimensional model was generated based on the Crystal Structure and assembly of eukaryotic small heat shock protein (PDB: 1GME) by using MODELLER7v7. The structure having a least modeller objective function was used as a starting point for picoseconds-duration molecular dynamics simulations. With the aid of the molecular dynamics and minimization methods, the final refined model was obtained and was further assessed by ERRAT, WHATCHECK and PROCHECK, which suggested that the refined model was reliable. Docking studies were performed by using the models with 2-mercaptoethanol and 3-amino- 5-methylhexanoic acid inhibitors. The results indicate that the 3-amino-5,5-diphenylpentanoic acid has more affinity than the other drug derivatives. The docking studies also suggest that MET-03, ARG-04, ASP-31, ALA-32, TRP-33, ARG-34, GLU-35 ARG-89, GLN-90 LEU-91 and VAL-92 are important determinant residues in binding with ligands. From the docking studies, we also suggest that GLU-35, in 18kDa protein domain is an important residue in binding.