Two Cases of Eruptive Pseudoangiomatosis / 대한피부과학회지

Eruptive pseudoandiomatosis (EPA) is a rare, self-limiting exanthem, which is characterized by numerous erythematous angioma-like papules surrounded by a pale halo. We report two cases of EPA, which developed in adulthood. The first patient, a 50-year-old female, had erythematous angioma-like papules surrounded by a pale halo on the face and arms. The second patient, a 34-year-old female, had lesions on the upper and lower extremities. The histological features included dilated blood vessels with plump endothelial cells, but there was no evidence of frank vascular proliferation or vasculitis.

Primary Cutaneous CD30-negative Large T-cell Lymphoma / 대한피부과학회지

Primary cutaneous CD30-negative large T-cell lymphoma without prior or concurrent mycosis fungoides represents a distinct group of cutaneous T-cell lymphoma with an aggressive clinical behavior. Primary cutaneous CD30-negative large T-cell lymphoma is a rare disorder which represents only about 5% of primary cutaneous T-cell lymphoma. A 51-year-old woman presented with a rapid growing, ulcerative plaque on the right lower leg of 2 years duration. Histologically, it showed diffuse infiltrates with a predominance of medium-sized to large pleomorphic lymphocytes in the dermis and subcutaneous fat layers, which stained positively with CD3 and negatively with CD20, CD30, CD56 on immunohistochemical staining. There was no evidence of extracutaneous metastsis.

Unilateral Localized Hyperhidrosis Over Scalp and Face / 대한피부과학회지

Unilateral localized hyperhidrosis over scalp and face is an extremely rare disease that usually has undetermined origin. We report a case of idiopathic unilateral localized hyperhidrosis over left scalp and face. A 55-year-old female patient with unilateral hyperhidrosis that is localized in the left side of scalp and face visited our dermatology clinic. She had increased sweating in left face and scalp, recurring in summer for 3 years. She complained of the exacerbation by thermal and gustatory stimuli and exercise. The starch iodine test and digital infrared thermal imaging test revealed a marked increase in sweat gland activity on the affected areas as compared to the contralateral normal sites.

Chemical Peeling and Laser Resurfacing

The chemical peeling is the process that involves the application of one or more exfoliating agents to the skin, resulting in the destruction of portions of the epidermis and/or dermis with subsequent regeneration. These techniques produce a controlled wound with instant vascular coagulation resulting in skin rejuvenenation with reduction or disappearance of actinic keratoses and changes, pigmentary dyschromias, rhytides, and selected superficial depressed scar. We herein introduce brief skin resurfacing techniques, indications, effectiveness, side effects of chemical peeling, dermabrasion, laser resurfacing.

A Case of Early-Onset Childhood Sarcoidosis / 대한피부과학회지

Early-onset childhood sarcoidosis is a unique form of the disease characterized by the triad of rash, uveitis, and arthritis in patients presenting before age 4 years. We report a case of early onset childhood sarcoidosis in a 4-year-old girl. She presented with fever, right ankle joint swelling, multiple skin lesions on whole body and was diagnosed as juvenile rheumatoid arthritis in padiatric department. She was transferred to dermatologic department for skin evaluation, histological investigation revealed well-circumscribed, non-caseating naked granuloma with epitheloid cells, histiocytes, lymphocytes on the upper dermis. Laboratory evaluation, chest X-ray, and ophthalmologic evaluation are all within normal limit. She is treated with systemic steroid, methotrexate, non-steroidal anti-inflammatory drugs and follow up evaluation will be planned for possible eye involvement.

A Case of Generalized Eruptive Histiocytoma in Childhood / 대한피부과학회지

Generalized eruptive histiocytoma is a papular, nonlipidic, self-healing histiocytosis affecting mainly adults. Clinically the disease is characterized by an asymptomatic, widespread, frequently symmetrical eruption of numerous dark red or bluish red papules. In adults the lesions are symmetrically distributed and may involve mucous membranes, while in children the lesions are irregularly scattered over the entire body and mucous membranes spare. We herein report a case of generalized eruptive histiocytoma developed in a 3-year-old boy. He was seen with brownish, flat papules on the face, trunk and both proximal portions of extremities. Histological and immunohistochemical investigation revealed monomorphous infiltration of S-100, CD1a negative, lysozyme positive histiocytes in the upper dermis. Neither cells with foamy cytoplasm nor giant cells was found. He did not show any disease progression without treatment, so now in regular follow-up for exaggeration.

Clinical Study of 11 Cases of Piebaldism in Koreans / 대한피부과학회지

BACKGROUND: Piebaldism is an uncommon congenital disease inherited in autosomal dominant pattern. It is characterized by stable leukoderma with white forelock and vitiligo-like amelanotic macules usually containing a few normally pigmented or hyperpigmented macules. There have been a few case reports, but no clinical study in Koreans. OBJECTIVE: The purpose of this study was to investigate characteristic clinical features in Korean patients with piebaldism different from that of Caucasian. METHODS: We evaluated 11 patients with piebaldism using retrospective method and telephone survey in regard to sex, family history, clinical features such as distribution of hypopigmented patches, white forelock, normo- or hyperpismented macules within hypopigmented patches, hyperpigmented macules in normal skin, associated systemic disease, and effect of treatment. RESULTS: Ten patients showed autosomal dominant features but one occurred sporadically. The ratio of male to female was 3:8, and only 6 patients had white forelock. The most common site of hypopigmented patches was the lower leg(in all patients), followed by abdomen, left foot and left buttock, and chest. All patients had normo- or hyperpismented macules in hypopigmented patches, and 4 had hyperpigmented lesion in normal skin. Down's syndrome was associated in one case. We treated 3 cases with epidermal graft. CONCLUSION: Most cases were consistent with other western reports. But our patients revealed female predominance(3:8), lower incidence of white forelock(about 55%), frequent lower leg involvement(100%), and uncommon distribution of skin lesion such as foot and buttock. These differences reflected characteristic clinical features of piebaldism in Koreans different from those of Caucasians.

A Case of Cutaneous Chylous Reflux / 대한피부과학회지

The term cutaneous chylous reflux refers to the back flow of chyle from its normal route and the discharge of chyle from the skin. Primary chylous reflux suggests the absence of an apparent etiology and may be due to malformations of mesenteric lymphatics. On the other hand, secondary chylous reflux is the result from irradiation, neoplasm, trauma and infection with filariasis. Here we report a case of primary cutaneous chylous reflux that has a unique clinical feature.

A Case of Giant Sebaceous Gland Hyperplasia / 대한피부과학회지

Sebaceous hyperplasia is not a rare disorder and commonly develops on the face over the age of forty. The typical clinical manifestations are 2 ~ 3mm sized, single or multiple, soft protuberant yellowish nodules with central umbilication and histology shows a group of mature sebaceous lobules and central sebaceous ducts. We report an exceptionally "giant" size of sebaceous gland hyperplasia which lead us to such clinical impressions as an acrochordon, intradermal nevus, and verruca vulgaris. Histologically, the lesion showed a greatly enlarged sebaceous gland composed of numerous lobules grouped around a wide sebaceous duct. Besides the extraordinarily large size of the nodule, the benign proliferating pattern led us to a diagnosis of giant sebaceous hyperplasia.

A Case of Linear Focal Elastosis / 대한피부과학회지

Linear focal elastosis was first described by Burket et al. in 1989 in three elderly men with palpable striae-like yellow bands on their backs. Microscopic examination revealed many fine wavy bundles of elastic fibers separating the collagen in the mid to reticular dermis. The patients' ages range a from 17 to 87 years but this disease seems to be more common in younger age; men are more commonly affected. The cause of this disease has been suggested to be hereditary predisposition, unusual form of striae distensae or keloidal repair of striae distensae. We report linear focal elatosis with typical clinical and pathological features in a 15-year-old boy.