RESUMO
In the present study peak expiratory flow rate (PEFR) were estimated in pregnant women during different trimester to observe the alteration in air flow rate during pregnancy. This study was carried out in the department of Physiology of Dhaka Medical College from July 2004 to June 2005. For this purpose, total 100 women with age ranged from 25 years to 35 years without any recent history of respiratory diseases were selected and divided into 25 healthy non-pregnant women as control and 75 normal pregnant women as study group. Study group was further divided into 25 in first trimesters, 25 in second trimester and 25 in third trimesters of pregnancy. All the subjects belonged to lower socioeconomic class. The PEFR was estimated by using an automatic spirometer. The measured values and percentage of predicted values of PEFR were estimated during the 1st, 2nd, 3rd trimesters of pregnant women and non-pregnant women. Statistical analysis of data were done by un paired student’s “t” test. The PEFR was significantly lower in both 2nd and 3rd trimester pregnant women than that of nonpregnant women. Again the PEFR was significantly lower in 3rd trimester than that of 1st trimester of pregnant women. There were no statistically significant difference of PEFR between the non-pregnant and 1st trimester; between the 1st trimester and 2nd trimeste ; and between the 2nd trimester and 3rd trimester of pregnant women. It may be concluded that PEFR were progressively decreased throughout the pregnancy, most likely due to mechanical effects of progressively increased size of uterus that progressively decreases lung volumes and capacities.
RESUMO
Objective: Percentage saturation of hemoglobin with oxygen in arterial blood (SaO2) was studied in pregnant women to evaluate the lung function status in pregnancy. Methods: This study was conducted in the department of physiology in Dhaka medical college during July 2004 to June 2005. For this purpose total 32 women with age ranged 25-35 years without any recent history of respiratory diseases were selected from Dhaka city. Eight (8) age matched apparently healthy women was taken as control and Twenty four (24) normal pregnant women without any complication were included in experimental group. All pregnant subjects were studied during first, second and third trimester. SaO2 was determined by “Easy Blood Gas Auto Analyzer”. SaO2 during different trimesters were compared with that of non pregnant and also among the trimesters. Statistical analysis was done by students unpaired ‘t’ test. Result: Mean ±SD SaO2 during first trimester (97.73%±0.92), second trimester (98.05%±0.54) and third trimester (98.40%±0.30) were progressively increasing and were significantly higher (p<0.05, p<0.001, p<0.001) than that of non pregnant women (96.71±0.63). But no statistically significant differences were observed among the trimesteric values. The present result indicates increased lung function in pregnant women associated with progressively increased oxygen saturation with trimester. Higher progesterone level is related to increased ventilation which is more marked in luteal phase of menstrual cycle. In pregnant women gradually rising progesterone level reaches its peak at the later part of pregnancy. Conclusion: Therefore it may be concluded from the present study that progressively increased SaO2 might be related to hyperventilation induced by high progesterone level.