RESUMO
Massoia (Cryptocarya massoia) is an Indonesian endemic plant containing essential oils with massoia lactone as adominant compound component. This study aims to clarify the inhalation effect of massoia lactone on body weight andlipid profile on Sprague Dawley rats. Chemical components of two fractionated portions among four fractions frommassoia oil were identified to be composed of 97% and 1.4% massoia lactone, thus named as massoia lactone rich andpoor fractions, respectively. The two fractions and massoia oil were further used for in vivo tests on four treatmentgroups (one group was negative control). The results showed that the experimental animals that inhaled massoialactone rich fraction had the lowest body weight analysis of variance (ANOVA p < 0.05), while the animals that inhaledmassoia oil and poor massoia lactone fraction had the lowest average cholesterol and triglyceride concentrations(ANOVA p < 0.05). These data indicate that the inhalation of fractionated massoia oil has the potential to decreasebody weight, restrain inclining of triglycerides and cholesterol concentration in the blood. Also, the number of livercells with a larger size than normal liver cells in rats with massoia lactone rich and poor fraction treatment was lessthan the negative control and treated with massoia oil.