RESUMO
Objective: To investigate the relationship between serum level of Apelin-13 and bone mineral density [BMD] as well as other parameters, and determine the influence of Apelin-13 on osteoporosis in patients with Type-2 diabetes mellitus
Methods: Seventy-six patients with Type-2 diabetes mellitus were recruited from Department of Endocrinology of our hospital between January 2013 and July 2017. The clinical data, including age, gender, height, weight, body mass index [BMI] and disease duration were recorded for all patients. Blood sample was collected for measurement of Apelin-13, Procollagen type-I N propeptide [PINP] and Cross-linked carboxy terminal telopeptide of type-I collagen [ICTP], and BMD was tested with a dual-energy X-ray absorptiometry scanner
Results: The patients were divided into three groups, in which 19 patients were assigned in osteoporosis group, 25 in osteopenia group and 32 in normal group. The level of Apelin-13 in osteoporosis group was significantly lower than that in osteopenia and normal groups [p<0.05], and the value in osteopenia group was significant lower than that in normal group [p<0.05]. Correlation analysis showed in the included patients the level of Apelin-13 was positively correlated to the value of BMD and PINP [p<0.05], but negatively correlated to age and ICTP [p<0.05]
Conclusion: In conclusion, this study demonstrated that there was a close relationship among Apelin-13, BMD, ICTP and PINP, and Apelin-13 plays an important role in the occurrence of osteoporosis in patients with Type-2 diabetes mellitus