Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Adicionar filtros








Intervalo de ano
1.
Artigo | IMSEAR | ID: sea-220708

RESUMO

PATTERNS OF SEROPREVALENCE FOR TRANSFUSION-TRANSMISSIBLE INFECTIONS AMONG BLOOD DONORS IN A BLOOD CENTRE OF NORTHEAST INDIA Original Research Paper Okram Geet- chandra Singh* Associate Professor, Blood Centre, JNIMS, Imphal *Corresponding Author Introduction: Transfusion– Transmissible Infections (TTIs) are the infections resulting from the introduction of a pathogen into a person through blood transfusion. In an attempt to mitigate the inherent risk of TTIs, the demographic information of blood donors including knowledge on local prevalence of infections and its pattern in the donor population is important for formulating recruitment strategies and planning other precautionary measures. Materials & Methods: This cross-sectional study was conducted in the Blood Centre, Jawaharlal Nehru Institute of Medical Sciences, Imphal between January 2019 and December 2022. All donated blood units were tested for the mandatory TTI markers for HIV 1 & 2, Hepatitis B, Hepatitis C, Syphilis and Malarial parasite. The prevalence and patterns of seropositivity for TTIs were studied based on the donor demographic characteristics such as donation type, gender and age group. The Results: overall seroprevalence among blood donors (n=31,563) was 1.79%. The seroprevalence was lower among voluntary donors (1.08%) than the replacement donors (2.10%). Seropositivities among female and male donors were 0.79% and 1.93% respectively. The lowest TTI seropositivity was seen among female voluntary donors (0.59%) and highest among male replacement donors (2.24%). The seroprevalence for speci?c TTI markers among the blood donors were 0.15% for HIV; 0.57% for HBV; 0.93% for HCV; 0.14% for Syphilis and no donor was found positive for Malaria. The frequency of TTI seropositivity was increased with increase in the age groups of donors in both sexes. There were 9 (0.029%) donors who had co-infection of TTIs. The patterns of TTI markers for co-infections were HCV+HIV=3; HCV+HBV=3; HCV+Syphilis=2 and HIV+ Syphilis=1. Conclusion: The measures to provide safe blood may include collection of blood from the targeted low risk donor population, using more sensitive testing methods, implementing pathogen reduction technologies and other public health measures

2.
Jordan Medical Journal. 1984; 18 (2): 159-66
em Inglês | IMEMR | ID: emr-4496

RESUMO

Peripheral natural cell-mediated cytotoxicity was studied in five patients with active discoid lupus erythematosus [DLE] and two patients with systemic lupus erythematosus [SLE]; one with active untreated disease and one under glucocorticosteriod treatment. Each patient was compared to a healthy control matching for the patient's age, sex and skin color. There was no significant difference between the DLE patients as a group and their respective controls, despite some moderate variation in their natural cell-mediated cytotoxicity. The untreated SLE patient showed a definite reduction in the natural cell-mediated cytotoxicity to 27.2% of that of the respective control. The glucocorticosteroid treated patient showed a normal level of natural cell-mediated cytotoxicity. The effect of the glucocorticosteroids is discussed in relation to their action on their immunological mechanisms


Assuntos
Dermatopatias , Lúpus Eritematoso Sistêmico , Imunidade Celular
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA